Synthesis and structure–activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells

A series of diarylamide derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2w was superior to the lead compound, Tranilast, in terms of the potency of the acti...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2001-02, Vol.11 (4), p.549-551
Hauptverfasser:	Ogita, Haruhisa, Isobe, Yoshiaki, Takaku, Haruo, Sekine, Rena, Goto, Yuso, Misawa, Satoru, Hayashi, Hideya
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemical synthesis Amides - pharmacology Animals Biological and medical sciences Cardiovascular system Cell Division - drug effects Coronary Disease - drug therapy Coronary Vessels - cytology Coronary Vessels - drug effects Medical sciences Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Pharmacology. Drug treatments Structure-Activity Relationship Vascular wall
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Zusammenfassung:	A series of diarylamide derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2w was superior to the lead compound, Tranilast, in terms of the potency of the activity and cell selectivity. A series of diarylamide derivatives were synthesized and evaluated for their inhibitory activities against the proliferation of human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs)
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(00)00717-4