Additional Cytotoxic Polyacetylenes from the Marine Sponge Petrosia Species
Ten new polyacetylenic alcohols (1−6, 8−11), along with a known compound, petrocortyne C (7), were isolated from the marine sponge Petrosia sp. The gross structures were established based on NMR and MS data, and the absolute configuration was determined by the modified Mosher's method. These co...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2001-01, Vol.64 (1), p.46-53 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | Lim, Young Ja Park, Hyun Sook Im, Kwang Sik Lee, Chong-O Hong, Jongki Lee, Min-Young Kim, Dong-kyoo Jung, Jee H |
| description | Ten new polyacetylenic alcohols (1−6, 8−11), along with a known compound, petrocortyne C (7), were isolated from the marine sponge Petrosia sp. The gross structures were established based on NMR and MS data, and the absolute configuration was determined by the modified Mosher's method. These compounds displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Compounds 1−11 were further evaluated for in vitro inhibitory activity on DNA replication. |
| doi_str_mv | 10.1021/np000252d |
| format | Article |
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The gross structures were established based on NMR and MS data, and the absolute configuration was determined by the modified Mosher's method. These compounds displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Compounds 1−11 were further evaluated for in vitro inhibitory activity on DNA replication.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np000252d</identifier><identifier>PMID: 11170665</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>alcohols ; Animals ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; DNA Replication - drug effects ; DNA, Viral - chemistry ; Drug Screening Assays, Antitumor ; General pharmacology ; Humans ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Medical sciences ; natural products ; petrocortyne C ; Petrosia ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Polyacetylenes ; Porifera - chemistry ; Simian virus 40 - chemistry ; Spectrometry, Mass, Fast Atom Bombardment ; Spectrophotometry, Ultraviolet ; Tumor Cells, Cultured</subject><ispartof>Journal of natural products (Washington, D.C.), 2001-01, Vol.64 (1), p.46-53</ispartof><rights>Copyright © 2001 American Chemical Society and American Society of Pharmacognosy</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a408t-4c36b7d3379db50bab7495d5fca0961c0699c8985500258330d0eb0cbe17c5463</citedby><cites>FETCH-LOGICAL-a408t-4c36b7d3379db50bab7495d5fca0961c0699c8985500258330d0eb0cbe17c5463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np000252d$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np000252d$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=880827$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11170665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lim, Young Ja</creatorcontrib><creatorcontrib>Park, Hyun Sook</creatorcontrib><creatorcontrib>Im, Kwang Sik</creatorcontrib><creatorcontrib>Lee, Chong-O</creatorcontrib><creatorcontrib>Hong, Jongki</creatorcontrib><creatorcontrib>Lee, Min-Young</creatorcontrib><creatorcontrib>Kim, Dong-kyoo</creatorcontrib><creatorcontrib>Jung, Jee H</creatorcontrib><title>Additional Cytotoxic Polyacetylenes from the Marine Sponge Petrosia Species</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Ten new polyacetylenic alcohols (1−6, 8−11), along with a known compound, petrocortyne C (7), were isolated from the marine sponge Petrosia sp. The gross structures were established based on NMR and MS data, and the absolute configuration was determined by the modified Mosher's method. These compounds displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Compounds 1−11 were further evaluated for in vitro inhibitory activity on DNA replication.</description><subject>alcohols</subject><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>DNA Replication - drug effects</subject><subject>DNA, Viral - chemistry</subject><subject>Drug Screening Assays, Antitumor</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Mass Spectrometry</subject><subject>Medical sciences</subject><subject>natural products</subject><subject>petrocortyne C</subject><subject>Petrosia</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyacetylenes</subject><subject>Porifera - chemistry</subject><subject>Simian virus 40 - chemistry</subject><subject>Spectrometry, Mass, Fast Atom Bombardment</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Tumor Cells, Cultured</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1rGzEQBmARGhon7aF_ICyUBnrYdLRafewxmLZpPqiLE-hNaLWzidL1ypVkiP99ZWycSyEnMehhmHeGkA8UzilU9Mu4BICKV90BmVBeQSly9YZMgApWMiXqI3Ic41NGDBr-lhxRSiUIwSfk-qLrXHJ-NEMxXSef_LOzxcwPa2MxrQccMRZ98IsiPWJxa4IbsZgv_fiAxQxT8NGZXKN1GN-Rw94MEd_v3hNy_-3r3fSyvPn5_cf04qY0NahU1paJVnaMyaZrObSmlXXDO95bA42gFkTTWNUozjehFGPQAbZgW6TS8lqwE3K27bsM_u8KY9ILFy0OgxnRr6LO0RitBbwKqVRcVJRl-HkLbQ4UA_Z6GdzChLWmoDcr1vsVZ3u6a7pqF9i9yN1OM_i4AyZaM_TBjNbFvVMKVCWzKrfKxYTP-18T_mghmeT6bjbXvy9rejWd_9KbET9tvbFRP_lVyBeL_xnvH6L-nNg</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>Lim, Young Ja</creator><creator>Park, Hyun Sook</creator><creator>Im, Kwang Sik</creator><creator>Lee, Chong-O</creator><creator>Hong, Jongki</creator><creator>Lee, Min-Young</creator><creator>Kim, Dong-kyoo</creator><creator>Jung, Jee H</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20010101</creationdate><title>Additional Cytotoxic Polyacetylenes from the Marine Sponge Petrosia Species</title><author>Lim, Young Ja ; Park, Hyun Sook ; Im, Kwang Sik ; Lee, Chong-O ; Hong, Jongki ; Lee, Min-Young ; Kim, Dong-kyoo ; Jung, Jee H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a408t-4c36b7d3379db50bab7495d5fca0961c0699c8985500258330d0eb0cbe17c5463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>alcohols</topic><topic>Animals</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>DNA Replication - drug effects</topic><topic>DNA, Viral - chemistry</topic><topic>Drug Screening Assays, Antitumor</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Mass Spectrometry</topic><topic>Medical sciences</topic><topic>natural products</topic><topic>petrocortyne C</topic><topic>Petrosia</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Polyacetylenes</topic><topic>Porifera - chemistry</topic><topic>Simian virus 40 - chemistry</topic><topic>Spectrometry, Mass, Fast Atom Bombardment</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lim, Young Ja</creatorcontrib><creatorcontrib>Park, Hyun Sook</creatorcontrib><creatorcontrib>Im, Kwang Sik</creatorcontrib><creatorcontrib>Lee, Chong-O</creatorcontrib><creatorcontrib>Hong, Jongki</creatorcontrib><creatorcontrib>Lee, Min-Young</creatorcontrib><creatorcontrib>Kim, Dong-kyoo</creatorcontrib><creatorcontrib>Jung, Jee H</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lim, Young Ja</au><au>Park, Hyun Sook</au><au>Im, Kwang Sik</au><au>Lee, Chong-O</au><au>Hong, Jongki</au><au>Lee, Min-Young</au><au>Kim, Dong-kyoo</au><au>Jung, Jee H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Additional Cytotoxic Polyacetylenes from the Marine Sponge Petrosia Species</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2001-01-01</date><risdate>2001</risdate><volume>64</volume><issue>1</issue><spage>46</spage><epage>53</epage><pages>46-53</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Ten new polyacetylenic alcohols (1−6, 8−11), along with a known compound, petrocortyne C (7), were isolated from the marine sponge Petrosia sp. The gross structures were established based on NMR and MS data, and the absolute configuration was determined by the modified Mosher's method. These compounds displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Compounds 1−11 were further evaluated for in vitro inhibitory activity on DNA replication.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>11170665</pmid><doi>10.1021/np000252d</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of natural products (Washington, D.C.), 2001-01, Vol.64 (1), p.46-53 |
| issn | 0163-3864 1520-6025 |
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| source | ACS Publications; MEDLINE |
| subjects | alcohols Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Chromatography, High Pressure Liquid DNA Replication - drug effects DNA, Viral - chemistry Drug Screening Assays, Antitumor General pharmacology Humans Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences natural products petrocortyne C Petrosia Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Polyacetylenes Porifera - chemistry Simian virus 40 - chemistry Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry, Ultraviolet Tumor Cells, Cultured |
| title | Additional Cytotoxic Polyacetylenes from the Marine Sponge Petrosia Species |
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