Additional Cytotoxic Polyacetylenes from the Marine Sponge Petrosia Species

Ten new polyacetylenic alcohols (1−6, 8−11), along with a known compound, petrocortyne C (7), were isolated from the marine sponge Petrosia sp. The gross structures were established based on NMR and MS data, and the absolute configuration was determined by the modified Mosher's method. These co...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2001-01, Vol.64 (1), p.46-53
Hauptverfasser:	Lim, Young Ja, Park, Hyun Sook, Im, Kwang Sik, Lee, Chong-O, Hong, Jongki, Lee, Min-Young, Kim, Dong-kyoo, Jung, Jee H
Format:	Artikel
Sprache:	eng
Schlagworte:	alcohols Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Chromatography, High Pressure Liquid DNA Replication - drug effects DNA, Viral - chemistry Drug Screening Assays, Antitumor General pharmacology Humans Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences natural products petrocortyne C Petrosia Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Polyacetylenes Porifera - chemistry Simian virus 40 - chemistry Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry, Ultraviolet Tumor Cells, Cultured
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Zusammenfassung:	Ten new polyacetylenic alcohols (1−6, 8−11), along with a known compound, petrocortyne C (7), were isolated from the marine sponge Petrosia sp. The gross structures were established based on NMR and MS data, and the absolute configuration was determined by the modified Mosher's method. These compounds displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Compounds 1−11 were further evaluated for in vitro inhibitory activity on DNA replication.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np000252d