Reversible folding-unfolding, aggregation protection, and multi-year stabilization, in high concentration protein solutions, using ionic liquids

Reversible folding-unfolding, aggregation protection, and multi-year stabilization, in high concentration protein solutions, using ionic liquids

We report the reversible thermal unfolding/refolding, and long period stabilization against aggregation and hydrolysis, of >200 mg ml(-1) solutions of lysozyme in ionic liquid-rich, ice-avoiding, solvents.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2007-01 (26), p.2714-2716
Hauptverfasser: Byrne, Nolene, Wang, Li-Min, Belieres, Jean-Philippe, Angell, C Austen
Format: Artikel
Sprache:eng
Schlagworte:
Ions
Protein Folding
Proteins - chemistry
Solutions
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Beschreibung
Zusammenfassung:We report the reversible thermal unfolding/refolding, and long period stabilization against aggregation and hydrolysis, of >200 mg ml(-1) solutions of lysozyme in ionic liquid-rich, ice-avoiding, solvents.
ISSN:1359-7345
1364-548X
DOI:10.1039/b618943a