Suppression of Experimental Autoimmune Uveoretinitis by Dietary Calorie Restriction
To investigate the inhibitory effect of dietary calorie restriction on experimental autoimmune uveoretinitis (EAU) in rats, and its mechanism. Lewis rats were maintained on a 50% calorie-restricted diet for 2 months or 6 months. The control group was maintained on a 90% ad libitum intake for the sam...
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| Veröffentlicht in: | Japanese journal of ophthalmology 2001-01, Vol.45 (1), p.46-52 |
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| container_title | Japanese journal of ophthalmology |
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| creator | Abe, Tohru Nakajima, Ako Satoh, Naoki Ohkoshi, Masatoshi Sakuragi, Shozo Koizumi, Akio |
| description | To investigate the inhibitory effect of dietary calorie restriction on experimental autoimmune uveoretinitis (EAU) in rats, and its mechanism.
Lewis rats were maintained on a 50% calorie-restricted diet for 2 months or 6 months. The control group was maintained on a 90% ad libitum intake for the same length of time. Experimental autoimmune uveoretinitis was elicited in both groups by immunization with an inter-photoreceptor retinoid-binding protein or its peptide. Rats in both groups were examined clinically, histopathologically, and immunologically.
The severity of EAU was milder in the restricted diet group than in the control group. In EAU rats, production of interferon-γ (IFN-γ) in eyes and of IFN-γ and tumor necrosis factor-α in draining lymph node cells was significantly lower in the restricted diet group than in the control group.
Our results indicate that a calorie-restricted diet suppresses the development of EAU. The suppressed Th1-dependent immunological response is one of the reasons for the mildness of EAU in the calorie-restricted diet group of rats. |
| doi_str_mv | 10.1016/S0021-5155(00)00303-8 |
| format | Article |
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Lewis rats were maintained on a 50% calorie-restricted diet for 2 months or 6 months. The control group was maintained on a 90% ad libitum intake for the same length of time. Experimental autoimmune uveoretinitis was elicited in both groups by immunization with an inter-photoreceptor retinoid-binding protein or its peptide. Rats in both groups were examined clinically, histopathologically, and immunologically.
The severity of EAU was milder in the restricted diet group than in the control group. In EAU rats, production of interferon-γ (IFN-γ) in eyes and of IFN-γ and tumor necrosis factor-α in draining lymph node cells was significantly lower in the restricted diet group than in the control group.
Our results indicate that a calorie-restricted diet suppresses the development of EAU. The suppressed Th1-dependent immunological response is one of the reasons for the mildness of EAU in the calorie-restricted diet group of rats.</description><identifier>ISSN: 0021-5155</identifier><identifier>EISSN: 1613-2246</identifier><identifier>DOI: 10.1016/S0021-5155(00)00303-8</identifier><identifier>PMID: 11163045</identifier><identifier>CODEN: JJOPA7</identifier><language>eng</language><publisher>Heidelberg: Elsevier Inc</publisher><subject>Animals ; Autoimmune Diseases - immunology ; Autoimmune Diseases - pathology ; Autoimmune Diseases - prevention & control ; Biological and medical sciences ; Cytokine ; Cytokines - metabolism ; dietary calorie restriction ; Dietary Carbohydrates - administration & dosage ; Energy Intake ; experimental autoimmune uveoretinitis ; Eye Proteins ; Immunoglobulin G - blood ; immunoregulation ; Leukocyte Count ; Lymphocyte Activation ; Male ; Medical sciences ; Models, Theoretical ; Ophthalmology ; Rats ; Rats, Inbred Lew ; Retinitis - immunology ; Retinitis - pathology ; Retinitis - prevention & control ; Retinol-Binding Proteins - immunology ; Retinopathies ; Uveitis - immunology ; Uveitis - pathology ; Uveitis - prevention & control</subject><ispartof>Japanese journal of ophthalmology, 2001-01, Vol.45 (1), p.46-52</ispartof><rights>2001 Japanese Ophthalmological Society</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-66a07476b66b913a66b24f7f56a73cd35ee70d19a0f7566fde54b31f8347f483</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=864885$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11163045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abe, Tohru</creatorcontrib><creatorcontrib>Nakajima, Ako</creatorcontrib><creatorcontrib>Satoh, Naoki</creatorcontrib><creatorcontrib>Ohkoshi, Masatoshi</creatorcontrib><creatorcontrib>Sakuragi, Shozo</creatorcontrib><creatorcontrib>Koizumi, Akio</creatorcontrib><title>Suppression of Experimental Autoimmune Uveoretinitis by Dietary Calorie Restriction</title><title>Japanese journal of ophthalmology</title><addtitle>Jpn J Ophthalmol</addtitle><description>To investigate the inhibitory effect of dietary calorie restriction on experimental autoimmune uveoretinitis (EAU) in rats, and its mechanism.
Lewis rats were maintained on a 50% calorie-restricted diet for 2 months or 6 months. The control group was maintained on a 90% ad libitum intake for the same length of time. Experimental autoimmune uveoretinitis was elicited in both groups by immunization with an inter-photoreceptor retinoid-binding protein or its peptide. Rats in both groups were examined clinically, histopathologically, and immunologically.
The severity of EAU was milder in the restricted diet group than in the control group. In EAU rats, production of interferon-γ (IFN-γ) in eyes and of IFN-γ and tumor necrosis factor-α in draining lymph node cells was significantly lower in the restricted diet group than in the control group.
Our results indicate that a calorie-restricted diet suppresses the development of EAU. The suppressed Th1-dependent immunological response is one of the reasons for the mildness of EAU in the calorie-restricted diet group of rats.</description><subject>Animals</subject><subject>Autoimmune Diseases - immunology</subject><subject>Autoimmune Diseases - pathology</subject><subject>Autoimmune Diseases - prevention & control</subject><subject>Biological and medical sciences</subject><subject>Cytokine</subject><subject>Cytokines - metabolism</subject><subject>dietary calorie restriction</subject><subject>Dietary Carbohydrates - administration & dosage</subject><subject>Energy Intake</subject><subject>experimental autoimmune uveoretinitis</subject><subject>Eye Proteins</subject><subject>Immunoglobulin G - blood</subject><subject>immunoregulation</subject><subject>Leukocyte Count</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Models, Theoretical</subject><subject>Ophthalmology</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Retinitis - immunology</subject><subject>Retinitis - pathology</subject><subject>Retinitis - prevention & control</subject><subject>Retinol-Binding Proteins - immunology</subject><subject>Retinopathies</subject><subject>Uveitis - immunology</subject><subject>Uveitis - pathology</subject><subject>Uveitis - prevention & control</subject><issn>0021-5155</issn><issn>1613-2246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVJaDZpf0KDIRDSg9uR9WHnFJZN0gYWCt30LGR5BAq25UpyyP77aLNLeuxpLs-878xDyBcK3yhQ-X0DUNFSUCGuAL4CMGBl84EsqKSsrCouj8jiHTkhpzE-AQCvWPWRnFBKJQMuFmSzmacpYIzOj4W3xd3LhMENOCbdF8s5eTcM84jFn2f0AZMbXXKxaLfFrcOkw7ZY6d4Hh8VvjCk4k3LOJ3JsdR_x82Gekcf7u8fVz3L968fDarkuDedVKqXUUPNatlK215TpPCpuayukrpnpmECsoaPXGmwtpLQdCt4yahvGa8sbdkYu97FT8H_nXK8GFw32vR7Rz1HVkH-kDWRQ7EETfIwBrZryi_l4RUHtZKo3mWpnSgGoN5lqV3B-KJjbAbt_Wwd7Gbg4ADoa3dugR-PiO9dI3jQ76mZPYXbx7DCoaByOBjsX0CTVefefQ14BGVCQmg</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>Abe, Tohru</creator><creator>Nakajima, Ako</creator><creator>Satoh, Naoki</creator><creator>Ohkoshi, Masatoshi</creator><creator>Sakuragi, Shozo</creator><creator>Koizumi, Akio</creator><general>Elsevier Inc</general><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010101</creationdate><title>Suppression of Experimental Autoimmune Uveoretinitis by Dietary Calorie Restriction</title><author>Abe, Tohru ; Nakajima, Ako ; Satoh, Naoki ; Ohkoshi, Masatoshi ; Sakuragi, Shozo ; Koizumi, Akio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-66a07476b66b913a66b24f7f56a73cd35ee70d19a0f7566fde54b31f8347f483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Autoimmune Diseases - immunology</topic><topic>Autoimmune Diseases - pathology</topic><topic>Autoimmune Diseases - prevention & control</topic><topic>Biological and medical sciences</topic><topic>Cytokine</topic><topic>Cytokines - metabolism</topic><topic>dietary calorie restriction</topic><topic>Dietary Carbohydrates - administration & dosage</topic><topic>Energy Intake</topic><topic>experimental autoimmune uveoretinitis</topic><topic>Eye Proteins</topic><topic>Immunoglobulin G - blood</topic><topic>immunoregulation</topic><topic>Leukocyte Count</topic><topic>Lymphocyte Activation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Models, Theoretical</topic><topic>Ophthalmology</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Retinitis - immunology</topic><topic>Retinitis - pathology</topic><topic>Retinitis - prevention & control</topic><topic>Retinol-Binding Proteins - immunology</topic><topic>Retinopathies</topic><topic>Uveitis - immunology</topic><topic>Uveitis - pathology</topic><topic>Uveitis - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abe, Tohru</creatorcontrib><creatorcontrib>Nakajima, Ako</creatorcontrib><creatorcontrib>Satoh, Naoki</creatorcontrib><creatorcontrib>Ohkoshi, Masatoshi</creatorcontrib><creatorcontrib>Sakuragi, Shozo</creatorcontrib><creatorcontrib>Koizumi, Akio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abe, Tohru</au><au>Nakajima, Ako</au><au>Satoh, Naoki</au><au>Ohkoshi, Masatoshi</au><au>Sakuragi, Shozo</au><au>Koizumi, Akio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression of Experimental Autoimmune Uveoretinitis by Dietary Calorie Restriction</atitle><jtitle>Japanese journal of ophthalmology</jtitle><addtitle>Jpn J Ophthalmol</addtitle><date>2001-01-01</date><risdate>2001</risdate><volume>45</volume><issue>1</issue><spage>46</spage><epage>52</epage><pages>46-52</pages><issn>0021-5155</issn><eissn>1613-2246</eissn><coden>JJOPA7</coden><abstract>To investigate the inhibitory effect of dietary calorie restriction on experimental autoimmune uveoretinitis (EAU) in rats, and its mechanism.
Lewis rats were maintained on a 50% calorie-restricted diet for 2 months or 6 months. The control group was maintained on a 90% ad libitum intake for the same length of time. Experimental autoimmune uveoretinitis was elicited in both groups by immunization with an inter-photoreceptor retinoid-binding protein or its peptide. Rats in both groups were examined clinically, histopathologically, and immunologically.
The severity of EAU was milder in the restricted diet group than in the control group. In EAU rats, production of interferon-γ (IFN-γ) in eyes and of IFN-γ and tumor necrosis factor-α in draining lymph node cells was significantly lower in the restricted diet group than in the control group.
Our results indicate that a calorie-restricted diet suppresses the development of EAU. The suppressed Th1-dependent immunological response is one of the reasons for the mildness of EAU in the calorie-restricted diet group of rats.</abstract><cop>Heidelberg</cop><pub>Elsevier Inc</pub><pmid>11163045</pmid><doi>10.1016/S0021-5155(00)00303-8</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Autoimmune Diseases - immunology Autoimmune Diseases - pathology Autoimmune Diseases - prevention & control Biological and medical sciences Cytokine Cytokines - metabolism dietary calorie restriction Dietary Carbohydrates - administration & dosage Energy Intake experimental autoimmune uveoretinitis Eye Proteins Immunoglobulin G - blood immunoregulation Leukocyte Count Lymphocyte Activation Male Medical sciences Models, Theoretical Ophthalmology Rats Rats, Inbred Lew Retinitis - immunology Retinitis - pathology Retinitis - prevention & control Retinol-Binding Proteins - immunology Retinopathies Uveitis - immunology Uveitis - pathology Uveitis - prevention & control |
| title | Suppression of Experimental Autoimmune Uveoretinitis by Dietary Calorie Restriction |
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