Heart rate variability in hypertrophic obstructive cardiomyopathy: association with functional classification and left ventricular outflow gradients
Background: The aim of this study was to investigate cardiac autonomic control in patients with hypertrophic obstructive cardiomyopathy (HOCM) and to assess the indexes of heart rate variability (HRV) in relation to the clinical and echocardiographic features. Methods and results: Twenty-three patie...
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| Veröffentlicht in: | International journal of cardiology 2001-02, Vol.77 (2), p.281-286 |
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| creator | Döven, Oben Sayin, Tamer Güldal, Muharrem Karaoǧuz, Remzi Oral, Derviş |
| description | Background: The aim of this study was to investigate cardiac autonomic control in patients with hypertrophic obstructive cardiomyopathy (HOCM) and to assess the indexes of heart rate variability (HRV) in relation to the clinical and echocardiographic features.
Methods and results: Twenty-three patients (17 male, six female: mean age 43±11) with HOCM and 18 healthy volunteers were included. M-mode and two-dimensional echocardiography, pulsed and continuous-wave Doppler studies were obtained. All patients and volunteers underwent continuous 24-h ambulatory ECG monitoring. Time domain variables considered in this study were standard deviation of mean R–R intervals (SDNN), root mean-squared successive difference (RMSSD) and percentage of cycles differing from the preceding one by more than 50 ms (PNN 50%). Patients were compared to detect associations between indices of heart rate variability, left ventricular outflow tract obstruction and clinical status. Heart rate variability parameters were also correlated with the echocardiographic and clinical characteristics of the patients. Both New York Heart Association (NYHA) functional class I–II patients (group I) and NYHA III–IV patients (group II) had lower values of SDNN, RMSSD and PNN 50% when compared with the control group (
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| doi_str_mv | 10.1016/S0167-5273(00)00447-2 |
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Methods and results: Twenty-three patients (17 male, six female: mean age 43±11) with HOCM and 18 healthy volunteers were included. M-mode and two-dimensional echocardiography, pulsed and continuous-wave Doppler studies were obtained. All patients and volunteers underwent continuous 24-h ambulatory ECG monitoring. Time domain variables considered in this study were standard deviation of mean R–R intervals (SDNN), root mean-squared successive difference (RMSSD) and percentage of cycles differing from the preceding one by more than 50 ms (PNN 50%). Patients were compared to detect associations between indices of heart rate variability, left ventricular outflow tract obstruction and clinical status. Heart rate variability parameters were also correlated with the echocardiographic and clinical characteristics of the patients. Both New York Heart Association (NYHA) functional class I–II patients (group I) and NYHA III–IV patients (group II) had lower values of SDNN, RMSSD and PNN 50% when compared with the control group (
P<0.001,
P<0.05 and
P<0.01, respectively, for group I and
P<0.001,
P<0.001 and
P<0.001, respectively, for group II). Time domain heart rate variability parameters were found to be significantly correlated with the subaortic dynamic obstruction.
Conclusion: Heart rate variability is reduced in HOCM and well correlated with the degree of subaortic obstruction. Heart rate variability indices are also sensitive markers of the functional status.]]></description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/S0167-5273(00)00447-2</identifier><identifier>PMID: 11182193</identifier><identifier>CODEN: IJCDD5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Autonomic Nervous System - physiopathology ; Biological and medical sciences ; Cardiomyopathy ; Cardiomyopathy, Hypertrophic - physiopathology ; Electrocardiography. Vectocardiography ; Electrodiagnosis. Electric activity recording ; Female ; Heart Rate ; Humans ; Hypertrophy ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Tropical medicine ; Ventricular Function, Left</subject><ispartof>International journal of cardiology, 2001-02, Vol.77 (2), p.281-286</ispartof><rights>2001 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-ddbed53f285d93ea9f34c1e7af3ea082d8bb3d4f60da7f1e544fac716fae2a93</citedby><cites>FETCH-LOGICAL-c389t-ddbed53f285d93ea9f34c1e7af3ea082d8bb3d4f60da7f1e544fac716fae2a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0167-5273(00)00447-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=900950$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11182193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Döven, Oben</creatorcontrib><creatorcontrib>Sayin, Tamer</creatorcontrib><creatorcontrib>Güldal, Muharrem</creatorcontrib><creatorcontrib>Karaoǧuz, Remzi</creatorcontrib><creatorcontrib>Oral, Derviş</creatorcontrib><title>Heart rate variability in hypertrophic obstructive cardiomyopathy: association with functional classification and left ventricular outflow gradients</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description><![CDATA[Background: The aim of this study was to investigate cardiac autonomic control in patients with hypertrophic obstructive cardiomyopathy (HOCM) and to assess the indexes of heart rate variability (HRV) in relation to the clinical and echocardiographic features.
Methods and results: Twenty-three patients (17 male, six female: mean age 43±11) with HOCM and 18 healthy volunteers were included. M-mode and two-dimensional echocardiography, pulsed and continuous-wave Doppler studies were obtained. All patients and volunteers underwent continuous 24-h ambulatory ECG monitoring. Time domain variables considered in this study were standard deviation of mean R–R intervals (SDNN), root mean-squared successive difference (RMSSD) and percentage of cycles differing from the preceding one by more than 50 ms (PNN 50%). Patients were compared to detect associations between indices of heart rate variability, left ventricular outflow tract obstruction and clinical status. Heart rate variability parameters were also correlated with the echocardiographic and clinical characteristics of the patients. Both New York Heart Association (NYHA) functional class I–II patients (group I) and NYHA III–IV patients (group II) had lower values of SDNN, RMSSD and PNN 50% when compared with the control group (
P<0.001,
P<0.05 and
P<0.01, respectively, for group I and
P<0.001,
P<0.001 and
P<0.001, respectively, for group II). Time domain heart rate variability parameters were found to be significantly correlated with the subaortic dynamic obstruction.
Conclusion: Heart rate variability is reduced in HOCM and well correlated with the degree of subaortic obstruction. Heart rate variability indices are also sensitive markers of the functional status.]]></description><subject>Adult</subject><subject>Autonomic Nervous System - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Cardiomyopathy</subject><subject>Cardiomyopathy, Hypertrophic - physiopathology</subject><subject>Electrocardiography. Vectocardiography</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Female</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Hypertrophy</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Tropical medicine</subject><subject>Ventricular Function, Left</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-KFDEQxoMo7uzqIygBQdZDa9J_pjt7EVnUFRY8uPdQnVSckkxnTNKz9Hv4wGZ2hvXopYrK96skfB9jr6R4L4Vcf_hRSl91dd9cCvFOiLbtq_oJW8mhbyvZd-1TtnpEzth5Sr9EoZQanrMzKeVQS9Ws2J8bhJh5hIx8D5FgJE954TTxzbLDmGPYbcjwMKYcZ5Npj9xAtBS2S9hB3ixXHFIKhiBTmPg95Q1382QOE3hufFHJkTnKMFnu0WW-xylHMrOHyMOcnQ_3_GcES-U8vWDPHPiEL0_9gt19-Xx3fVPdfv_67frTbWWaQeXK2hFt17h66KxqEJRrWiOxB1cGMdR2GMfGtm4tLPROYte2Dkwv1w6wBtVcsLfHa3cx_J4xZb2lZNB7mDDMSfdiXSvRdAXsjqCJIaWITu8ibSEuWgp9SEM_pKEPVmsh9EMaui57r08PzOMW7b-tk_0FeHMCIBnwLsJkKD1ySgjViUJ9PFJYvNgTRp1M8cmgpYgmaxvoPx_5CxAgrNg</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Döven, Oben</creator><creator>Sayin, Tamer</creator><creator>Güldal, Muharrem</creator><creator>Karaoǧuz, Remzi</creator><creator>Oral, Derviş</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010201</creationdate><title>Heart rate variability in hypertrophic obstructive cardiomyopathy: association with functional classification and left ventricular outflow gradients</title><author>Döven, Oben ; Sayin, Tamer ; Güldal, Muharrem ; Karaoǧuz, Remzi ; Oral, Derviş</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-ddbed53f285d93ea9f34c1e7af3ea082d8bb3d4f60da7f1e544fac716fae2a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Autonomic Nervous System - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Cardiomyopathy</topic><topic>Cardiomyopathy, Hypertrophic - physiopathology</topic><topic>Electrocardiography. Vectocardiography</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Female</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>Hypertrophy</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Tropical medicine</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Döven, Oben</creatorcontrib><creatorcontrib>Sayin, Tamer</creatorcontrib><creatorcontrib>Güldal, Muharrem</creatorcontrib><creatorcontrib>Karaoǧuz, Remzi</creatorcontrib><creatorcontrib>Oral, Derviş</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Döven, Oben</au><au>Sayin, Tamer</au><au>Güldal, Muharrem</au><au>Karaoǧuz, Remzi</au><au>Oral, Derviş</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heart rate variability in hypertrophic obstructive cardiomyopathy: association with functional classification and left ventricular outflow gradients</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>77</volume><issue>2</issue><spage>281</spage><epage>286</epage><pages>281-286</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><coden>IJCDD5</coden><abstract><![CDATA[Background: The aim of this study was to investigate cardiac autonomic control in patients with hypertrophic obstructive cardiomyopathy (HOCM) and to assess the indexes of heart rate variability (HRV) in relation to the clinical and echocardiographic features.
Methods and results: Twenty-three patients (17 male, six female: mean age 43±11) with HOCM and 18 healthy volunteers were included. M-mode and two-dimensional echocardiography, pulsed and continuous-wave Doppler studies were obtained. All patients and volunteers underwent continuous 24-h ambulatory ECG monitoring. Time domain variables considered in this study were standard deviation of mean R–R intervals (SDNN), root mean-squared successive difference (RMSSD) and percentage of cycles differing from the preceding one by more than 50 ms (PNN 50%). Patients were compared to detect associations between indices of heart rate variability, left ventricular outflow tract obstruction and clinical status. Heart rate variability parameters were also correlated with the echocardiographic and clinical characteristics of the patients. Both New York Heart Association (NYHA) functional class I–II patients (group I) and NYHA III–IV patients (group II) had lower values of SDNN, RMSSD and PNN 50% when compared with the control group (
P<0.001,
P<0.05 and
P<0.01, respectively, for group I and
P<0.001,
P<0.001 and
P<0.001, respectively, for group II). Time domain heart rate variability parameters were found to be significantly correlated with the subaortic dynamic obstruction.
Conclusion: Heart rate variability is reduced in HOCM and well correlated with the degree of subaortic obstruction. Heart rate variability indices are also sensitive markers of the functional status.]]></abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11182193</pmid><doi>10.1016/S0167-5273(00)00447-2</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Autonomic Nervous System - physiopathology Biological and medical sciences Cardiomyopathy Cardiomyopathy, Hypertrophic - physiopathology Electrocardiography. Vectocardiography Electrodiagnosis. Electric activity recording Female Heart Rate Humans Hypertrophy Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Tropical medicine Ventricular Function, Left |
| title | Heart rate variability in hypertrophic obstructive cardiomyopathy: association with functional classification and left ventricular outflow gradients |
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