Polymorphisms in the Human SNAIL (SNAI1) gene

The human SNAIL is an important developmental protein involved in the formation of mesoderm and neural crest. The protein contains three classic and one atypical zinc-finger motif. The SNAI1 gene is composed of three exons. We have identified three SNPs in non-coding regions, two in the 5′UTR and on...

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Veröffentlicht in:	Molecular and cellular probes 2001-02, Vol.15 (1), p.53-55
Hauptverfasser:	Okajima, K., Paznekas, W.A., Burstyn, T., Jabs, E.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Alleles Base Sequence DNA-Binding Proteins - genetics Exons Heterozygote Humans Introns Molecular Sequence Data Mutation Polymerase Chain Reaction Polymorphism, Genetic Snail Family Transcription Factors snail, single nucleotide polymorphism (SNP), zinc finger protein Transcription Factors - genetics Zinc Fingers
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Beschreibung
Zusammenfassung:	The human SNAIL is an important developmental protein involved in the formation of mesoderm and neural crest. The protein contains three classic and one atypical zinc-finger motif. The SNAI1 gene is composed of three exons. We have identified three SNPs in non-coding regions, two in the 5′UTR and one in intron 1, which can be detected by PCR followed by restriction enzyme digestion. We also identified a GGG/GGGG polymorphism in intron 1. We screened CEPH DNAs for these polymorphisms.
ISSN:	0890-8508 1096-1194
DOI:	10.1006/mcpr.2000.0332