Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study

Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study

Summary Background Although umbilical cord blood is an accepted alternative to bone marrow for transplantation, allele-matched bone marrow is generally regarded as the preferred graft source. Our aim was to assess leukaemia-free survival after transplantations of these alternatives compared with pre...

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Veröffentlicht in:The Lancet (British edition) 2007-06, Vol.369 (9577), p.1947-1954
Hauptverfasser: Eapen, Mary, MRCPI, Rubinstein, Pablo, MD, Zhang, Mei-Jie, PhD, Stevens, Cladd, MD, Kurtzberg, Joanne, MD, Scaradavou, Andromachi, MD, Loberiza, Fausto R, MD, Champlin, Richard E, MD, Klein, John P, PhD, Horowitz, Mary M, MD, Wagner, John E, Dr
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Alleles
Blood
Bone marrow
Bone Marrow Transplantation
Child
Child, Preschool
Children & youth
Fetal Blood
Graft vs Host Disease - prevention & control
Hematopoietic Stem Cell Transplantation
Histocompatibility Testing
Humans
Infant
Internal Medicine
Leukemia
Leukemia, Myeloid, Acute - therapy
Mortality
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Risk reduction
Stem cells
Survival
Transplantation
Transplants & implants
Treatment Failure
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Zusammenfassung:Summary Background Although umbilical cord blood is an accepted alternative to bone marrow for transplantation, allele-matched bone marrow is generally regarded as the preferred graft source. Our aim was to assess leukaemia-free survival after transplantations of these alternatives compared with present HLA-matching practices, and to assess the relative effect of cell dose and HLA match, and their potential interaction on leukaemia-free survival after cord-blood transplantation. Methods Outcomes of 503 children (
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(07)60915-5