Effect of intra-arterial papaverine on regional cerebral blood flow in hemodynamically relevant cerebral vasospasm

It remains controversial whether the intra-arterial administration of papaverine (IAP) is effective in reversing vasospasm-associated cerebral hypoperfusion after aneurysmal subarachnoid hemorrhage. The aim of the present study was to continuously assess regional cerebral blood flow (rCBF) during an...

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Veröffentlicht in:	Stroke (1970) 2001-02, Vol.32 (2), p.498-505
Hauptverfasser:	VAJKOCZY, Peter, HORN, Peter, BAUHUF, Christian, MUNCH, Elke, HUBNER, Ulrich, THOME, Claudius, POECKLER-SCHOENINGER, Christiane, ROTH, Harry, SCHMIEDEK, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Blood Flow Velocity - drug effects Blood Pressure - drug effects Cardiovascular system Cerebrovascular Circulation - drug effects Electrodes, Implanted Female Humans Injections, Intra-Arterial Male Medical sciences Microcirculation - diagnostic imaging Microcirculation - drug effects Middle Aged Papaverine - administration & dosage Pharmacology. Drug treatments Prospective Studies Reproducibility of Results Rheology Subarachnoid Hemorrhage - complications Subarachnoid Hemorrhage - diagnostic imaging Subarachnoid Hemorrhage - physiopathology Treatment Failure Ultrasonography, Doppler, Transcranial Vascular Resistance - drug effects Vasodilator Agents - administration & dosage Vasodilator agents. Cerebral vasodilators Vasospasm, Intracranial - complications Vasospasm, Intracranial - drug therapy Vasospasm, Intracranial - physiopathology
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Zusammenfassung:	It remains controversial whether the intra-arterial administration of papaverine (IAP) is effective in reversing vasospasm-associated cerebral hypoperfusion after aneurysmal subarachnoid hemorrhage. The aim of the present study was to continuously assess regional cerebral blood flow (rCBF) during and after IAP with the use of quantitative, bedside thermal diffusion flowmetry. Eight patients with cerebral vasospasm after subarachnoid hemorrhage (mean flow velocity >120 cm/s; angiographic vessel constriction >33%; hemispheric cerebral blood flow [CBF]
ISSN:	0039-2499 1524-4628
DOI:	10.1161/01.str.32.2.498