A modification of NIH consensus criteria to better distinguish the highly lethal subset of primary localized gastrointestinal stromal tumors: A subdivision of the original high-risk group on the basis of outcome

Background By reappraising the National Institutes of Health (NIH) consensus criteria, we worked on establishing a modified scheme to identify highly lethal gastrointestinal stromal tumors (GISTs), which have an imperative demand for sequencing analysis to assess the suitability of an adjuvant imati...

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Veröffentlicht in:	Surgery 2007-06, Vol.141 (6), p.748-756
Hauptverfasser:	Huang, Hsuan-Ying, MD, Li, Chien-Feng, MD, Huang, Wen-Wei, MD, Hu, Tsung-Hui, MD, Lin, Ching-Nan, MD, Uen, Yih-Huei, MD, Hsiung, Ching-Yeh, MD, Lu, David, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Cohort Studies Consensus Female Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal Stromal Tumors - classification Gastrointestinal Stromal Tumors - diagnosis Gastrointestinal Stromal Tumors - pathology Gastrointestinal Stromal Tumors - therapy General aspects Humans Male Medical sciences Middle Aged Multivariate Analysis National Institutes of Health (U.S.) Prognosis Retrospective Studies Risk Assessment Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery Survival Analysis Treatment Outcome Tumors United States
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Zusammenfassung:	Background By reappraising the National Institutes of Health (NIH) consensus criteria, we worked on establishing a modified scheme to identify highly lethal gastrointestinal stromal tumors (GISTs), which have an imperative demand for sequencing analysis to assess the suitability of an adjuvant imatinib trial. Methods Clinicopathologic features, including NIH and modified schemes, were retrospectively analyzed for 289 patients with localized GISTs. We combined the very low/low-risk GISTs into a single “risk level I” group (≦5 cm,
ISSN:	0039-6060 1532-7361
DOI:	10.1016/j.surg.2007.01.024