Synthesis and antibacterial activity of 3-keto-6- O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives

A series of 3-keto-6- O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives has been synthesized. The best compounds in this series possess potent in vitro antibacterial activity against erythromycin-susceptible and erythromycin-resistant bacteria. A series of 3-keto-6- O-carbamoyl-11,12...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-07, Vol.17 (14), p.3900-3904
Hauptverfasser:	Zhu, Bin, Marinelli, Brett A., Abbanat, Darren, Foleno, Barbara D., Bush, Karen, Macielag, Mark J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Erythromycin - analogs & derivatives Erythromycin - chemical synthesis Erythromycin - pharmacology Erythromycin A Ketolide Macrolide Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Staphylococcus aureus - drug effects Streptococcus pneumoniae - drug effects
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Zusammenfassung:	A series of 3-keto-6- O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives has been synthesized. The best compounds in this series possess potent in vitro antibacterial activity against erythromycin-susceptible and erythromycin-resistant bacteria. A series of 3-keto-6- O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives has been synthesized. The best compounds in this series possess potent in vitro antibacterial activity against erythromycin-susceptible and erythromycin-resistant bacteria.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2007.04.104