Imject® Alum is not aluminum hydroxide adjuvant or aluminum phosphate adjuvant

According to the information supplied by Pierce, Imject® Alum contains aluminum hydroxide (40mg/mL) and magnesium hydroxide (40mg/mL) and inactive stabilizers [1]. While we do not dispute the efficacy of Imject® Alum as an adjuvant, the composition of Imject® Alum is not equivalent to either of the...

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Veröffentlicht in:	Vaccine 2007-06, Vol.25 (27), p.4985-4986
Hauptverfasser:	Hem, Stanley L, Johnston, Cliff T, HogenEsch, Harm
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants, Immunologic - analysis Allergy and Immunology Alum Alum Compounds - analysis Aluminum Aluminum Compounds - analysis Aluminum Hydroxide - analysis Aluminum hydroxide adjuvant Aluminum phosphate adjuvant Applied microbiology Biological and medical sciences Chemical industry Fire resistant materials Fundamental and applied biological sciences. Psychology Imject ® Alum Licenses Magnesium hydroxide Microbiology Phosphates - analysis Spectroscopy, Fourier Transform Infrared Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Beschreibung
Zusammenfassung:	According to the information supplied by Pierce, Imject® Alum contains aluminum hydroxide (40mg/mL) and magnesium hydroxide (40mg/mL) and inactive stabilizers [1]. While we do not dispute the efficacy of Imject® Alum as an adjuvant, the composition of Imject® Alum is not equivalent to either of the aluminum-containing adjuvants that are used in licensed vaccines. [...]we recommend that Imject® Alum not be used in research when the intent is to study the effect of either aluminum hydroxide adjuvant or aluminum phosphate adjuvant.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2007.04.078