Abyssomicin E, a Highly Functionalized Polycyclic Metabolite from Streptomyces Species

Abyssomicin E, a Highly Functionalized Polycyclic Metabolite from Streptomyces Species

Abyssomicin E (1), a new polycyclic metabolite with a C19 skeleton, was isolated from Streptomyces sp. (HKI0381). Its chemical structure was determined by comprehensive NMR and MS spectroscopic analyses. For the first time in this recently discovered class of compounds, the absolute stereochemistry...

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Veröffentlicht in:Organic letters 2007-06, Vol.9 (13), p.2437-2440
Hauptverfasser: Niu, Xue-Mei, Li, Sheng-Hong, Görls, Helmar, Schollmeyer, Dieter, Hilliger, Matthias, Grabley, Susanne, Sattler, Isabel
Format: Artikel
Sprache:eng
Schlagworte:
Bridged Bicyclo Compounds, Heterocyclic - chemistry
Bridged Bicyclo Compounds, Heterocyclic - isolation & purification
Bridged Bicyclo Compounds, Heterocyclic - metabolism
Models, Molecular
Molecular Structure
Streptomyces - chemistry
Streptomyces - classification
Streptomyces - metabolism
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Zusammenfassung:Abyssomicin E (1), a new polycyclic metabolite with a C19 skeleton, was isolated from Streptomyces sp. (HKI0381). Its chemical structure was determined by comprehensive NMR and MS spectroscopic analyses. For the first time in this recently discovered class of compounds, the absolute stereochemistry was directly established by subsequent single-crystal X-ray diffraction study using anomalous dispersion with copper radiation.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0705999