Fumimycin:  A Peptide Deformylase Inhibitor with an Unusual Skeleton Produced by Aspergillus fumisynnematus

Fumimycin:  A Peptide Deformylase Inhibitor with an Unusual Skeleton Produced by Aspergillus fumisynnematus

Fumimycin, an unusual metabolite incorporating an unusual alanine unit linked to a phenyl group at the α-carbon with both lactone and amide moieties, was isolated from cultures of Aspergillus fumisynnematus. Its structure was established by spectral analysis. Fumimycin was found to inhibit Staphyloc...

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Veröffentlicht in:Organic letters 2007-06, Vol.9 (13), p.2449-2451
Hauptverfasser: Kwon, Yun-Ju, Sohn, Mi-Jin, Zheng, Chang-Ji, Kim, Won-Gon
Format: Artikel
Sprache:eng
Schlagworte:
Amidohydrolases - antagonists & inhibitors
Aspergillus - chemistry
Aspergillus - metabolism
Benzofurans - chemistry
Benzofurans - metabolism
Benzofurans - pharmacology
Molecular Structure
Staphylococcus aureus - enzymology
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Zusammenfassung:Fumimycin, an unusual metabolite incorporating an unusual alanine unit linked to a phenyl group at the α-carbon with both lactone and amide moieties, was isolated from cultures of Aspergillus fumisynnematus. Its structure was established by spectral analysis. Fumimycin was found to inhibit Staphylococcus aureus peptide deformylase with an IC50 value of 4.1 μΜ and also showed antibacterial activity against S. aureus.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0703231