bioactive polyacetylene compound isolated from Centella asiatica

Abstract A polyacetylene compound was isolated from the aerial parts of CENTELLA ASIATICA. The chemical structure of this new compound was identified as methyl 5-[(E)-9-hydroxy-1-(1-hydroxyhexyl)-2-methoxyundeca-3,10-diene-5,7-diynyloxy]pentanoate (cadiyenol). This compound induces apoptosis (63 %)...

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Veröffentlicht in:	Planta medica 2007-06, Vol.73 (6), p.597-599
Hauptverfasser:	Govindan, G, Sambandan, T.G, Govindan, M, Sinskey, A, Vanessendelft, J, Adenan, I, Rha, C.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anticarcinogenic activity Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Apiaceae apoptosis Apoptosis - drug effects Biological and medical sciences cadiyenol Cell Line, Tumor - drug effects Centella Centella asiatica chemical structure cultured cells General pharmacology Humans Medical sciences medicinal properties methyl 5-[(E)-9-hydroxy-1-(1-hydroxyhexyl)-2-methoxyundeca-3,10-diene-5,7-diynyloxy]pentanoate Mice Natural Product Chemistry nitric oxide Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use polyacetylenes Polyacetylenes - administration & dosage Polyacetylenes - chemistry Polyacetylenes - pharmacology Polyacetylenes - therapeutic use spectral analysis stereochemistry
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Zusammenfassung:	Abstract A polyacetylene compound was isolated from the aerial parts of CENTELLA ASIATICA. The chemical structure of this new compound was identified as methyl 5-[(E)-9-hydroxy-1-(1-hydroxyhexyl)-2-methoxyundeca-3,10-diene-5,7-diynyloxy]pentanoate (cadiyenol). This compound induces apoptosis (63 %) independent of cell cycle regimen in mouse lymphoma cells (P388D1) at 28 μM (IC 50 = 24 ± 2 μM) in 24 hours. The compound also reduces nitric oxide production by 70 ± 2 % in lipopolysacharride-activated mouse macrophages at 24 μM with no measurable cytotoxicity.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2007-981521