Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity

Orexin-A and orexin-B are hypothalamic neuropeptides derived from a 130-amino acid precursor, prepro-orexin, and are potent agonists at both the orexin-1 (OX1) and orexin-2 (OX2) receptors. Orexin-A has been ascribed a number of in vivo functions in the rat after intracerebroventricular (ICV) admini...

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Veröffentlicht in:	Psychopharmacologia 2001-01, Vol.153 (2), p.210-218
Hauptverfasser:	JONES, Declan N. C, GARTLON, Jane, PORTER, Rod A, HAGAN, Jim J, HUNTER, A. Jackie, UPTON, Neil, PARKER, Frederick, TAYLOR, Stephen G, ROUTLEDGE, Carol, HEMMATI, Panida, MUNTON, Richard P, ASHMEADE, Tracey E, HATCHER, Jonathan P, JOHNS, Amanda
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Behavioral psychophysiology Benzoxazoles - pharmacology Biological and medical sciences Body temperature Body Temperature - drug effects Brain Chemistry - drug effects Carrier Proteins - pharmacology Corticosterone Environmental monitoring Fundamental and applied biological sciences. Psychology Grooming Grooming - drug effects Hyperactivity Hyperphagia Hypothalamus Intracellular Signaling Peptides and Proteins Miscellaneous Motor activity Motor Activity - drug effects Neostriatum Neuroendocrine system Neuromodulation Neuropeptides Neuropeptides - pharmacology Neurosecretory Systems - drug effects orexin A orexin B Orexin Receptors Orexins Plasma Prolactin Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Receptor mechanisms Receptors, G-Protein-Coupled Receptors, Neuropeptide - drug effects Reflex, Startle - drug effects Sleep and wakefulness Urea - analogs & derivatives Urea - pharmacology Ventricles (cerebral)
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