Endocytosis of Uncleaved Tumor Necrosis Factor-α in Macrophages

Activated monocytes and macrophages secrete the inflammatory cytokine tumor necrosis factor-α (TNF-α). TNF-α is produced as a 26 kd transmembrane protein that is cleaved to release a 17 kd soluble protein. TNF-α in both forms is biologically active. The intracellular trafficking of membrane-associat...

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Veröffentlicht in:	Laboratory investigation 2001-01, Vol.81 (1), p.107-117
Hauptverfasser:	Shurety, Wenda, Pagan, Julia K, Prins, Johannes B, Stow, Jennifer L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cell Line Cell Membrane - immunology Endocytosis Fundamental and applied biological sciences. Psychology Golgi Apparatus - immunology Hydroxamic Acids - pharmacology Immunohistochemistry Inflammation Laboratory Medicine Lipopolysaccharides - pharmacology Macrophage Activation Macrophages - drug effects Macrophages - immunology Medicine Medicine & Public Health Metalloendopeptidases - antagonists & inhibitors Mice Molecular and cellular biology Molecular Weight Pathology Protease Inhibitors - pharmacology Protein hormones. Growth factors. Cytokines Proteins Tumor Necrosis Factor-alpha - chemistry Tumor Necrosis Factor-alpha - metabolism
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