Temporal changes in cardiac function and cerebral blood flow during sequential postmenopausal hormone replacement
Objective: The purpose was to assess the temporal changes in cardiac function and cerebral blood flow during postmenopausal administration of estrogen with and without progestogen. Study Design: Sixteen postmenopausal volunteers were assessed during estradiol plus sequential norethindrone acetate an...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2001-01, Vol.184 (2), p.41-47 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Sørensen, Morten B. Fritz-Hansen, Thomas Jensen, Henrik H. Pedersen, Anette T. Højgaard, Liselotte Ottesen, Bent |
| description | Objective: The purpose was to assess the temporal changes in cardiac function and cerebral blood flow during postmenopausal administration of estrogen with and without progestogen. Study Design: Sixteen postmenopausal volunteers were assessed during estradiol plus sequential norethindrone acetate and placebo in two 12-week periods. Temporal changes were measured by magnetic resonance flow mapping 8 times. Results: Systemic vascular resistance was reduced during estradiol (–6.9%; P |
| doi_str_mv | 10.1067/mob.2001.108333 |
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Study Design: Sixteen postmenopausal volunteers were assessed during estradiol plus sequential norethindrone acetate and placebo in two 12-week periods. Temporal changes were measured by magnetic resonance flow mapping 8 times. Results: Systemic vascular resistance was reduced during estradiol (–6.9%; P <.05), declined further during the addition of norethindrone acetate, and was accompanied by an increase in stroke volume (maximum increase, 5.2%; P <.05) without fluid retention. Both systolic (–5 mm Hg; P =.03) and diastolic (–3 mm Hg; P =.03) blood pressure were reduced during estradiol. Cerebral blood flow was reduced after 9 weeks of hormone replacement therapy (–37 mL/min; P =.01) but increased to baseline after the addition of norethindrone acetate. Conclusions: Sequential hormone replacement therapy is associated with changes in cardiac function, which are of therapeutic potential in cardiovascular disorders. Sequential hormone replacement therapy exhibits an overall neutral effect on cerebral blood flow. (Am J Obstet Gynecol 2001;184:41-7.)</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1067/mob.2001.108333</identifier><identifier>PMID: 11174477</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Biological and medical sciences ; Blood Pressure - drug effects ; cardiac function ; Cardiovascular Diseases - prevention & control ; cerebral blood flow ; Cerebrovascular Circulation ; Cross-Over Studies ; Double-Blind Method ; Estradiol - administration & dosage ; Estradiol - blood ; Estrogen Replacement Therapy ; Estrogens ; Female ; Genital system. Reproduction ; Heart - physiology ; Humans ; Magnetic Resonance Angiography ; Medical sciences ; menopause ; Middle Aged ; norethindrone ; Norethindrone - administration & dosage ; Norethindrone - analogs & derivatives ; Pharmacology. Drug treatments ; Placebos ; Postmenopause ; Stroke Volume - drug effects ; Vascular Resistance - drug effects</subject><ispartof>American journal of obstetrics and gynecology, 2001-01, Vol.184 (2), p.41-47</ispartof><rights>2001 Mosby, Inc.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-ca1c10c811316b9d37b4932a23668dd617bc57f14cf34b61fc7da65acc79ab0c3</citedby><cites>FETCH-LOGICAL-c462t-ca1c10c811316b9d37b4932a23668dd617bc57f14cf34b61fc7da65acc79ab0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1067/mob.2001.108333$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,4023,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=861225$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11174477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sørensen, Morten B.</creatorcontrib><creatorcontrib>Fritz-Hansen, Thomas</creatorcontrib><creatorcontrib>Jensen, Henrik H.</creatorcontrib><creatorcontrib>Pedersen, Anette T.</creatorcontrib><creatorcontrib>Højgaard, Liselotte</creatorcontrib><creatorcontrib>Ottesen, Bent</creatorcontrib><title>Temporal changes in cardiac function and cerebral blood flow during sequential postmenopausal hormone replacement</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective: The purpose was to assess the temporal changes in cardiac function and cerebral blood flow during postmenopausal administration of estrogen with and without progestogen. Study Design: Sixteen postmenopausal volunteers were assessed during estradiol plus sequential norethindrone acetate and placebo in two 12-week periods. Temporal changes were measured by magnetic resonance flow mapping 8 times. Results: Systemic vascular resistance was reduced during estradiol (–6.9%; P <.05), declined further during the addition of norethindrone acetate, and was accompanied by an increase in stroke volume (maximum increase, 5.2%; P <.05) without fluid retention. Both systolic (–5 mm Hg; P =.03) and diastolic (–3 mm Hg; P =.03) blood pressure were reduced during estradiol. Cerebral blood flow was reduced after 9 weeks of hormone replacement therapy (–37 mL/min; P =.01) but increased to baseline after the addition of norethindrone acetate. Conclusions: Sequential hormone replacement therapy is associated with changes in cardiac function, which are of therapeutic potential in cardiovascular disorders. Sequential hormone replacement therapy exhibits an overall neutral effect on cerebral blood flow. (Am J Obstet Gynecol 2001;184:41-7.)</description><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>cardiac function</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>cerebral blood flow</subject><subject>Cerebrovascular Circulation</subject><subject>Cross-Over Studies</subject><subject>Double-Blind Method</subject><subject>Estradiol - administration & dosage</subject><subject>Estradiol - blood</subject><subject>Estrogen Replacement Therapy</subject><subject>Estrogens</subject><subject>Female</subject><subject>Genital system. Reproduction</subject><subject>Heart - physiology</subject><subject>Humans</subject><subject>Magnetic Resonance Angiography</subject><subject>Medical sciences</subject><subject>menopause</subject><subject>Middle Aged</subject><subject>norethindrone</subject><subject>Norethindrone - administration & dosage</subject><subject>Norethindrone - analogs & derivatives</subject><subject>Pharmacology. Drug treatments</subject><subject>Placebos</subject><subject>Postmenopause</subject><subject>Stroke Volume - drug effects</subject><subject>Vascular Resistance - drug effects</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1r3DAQhkVpaLZJz70VQaE3JxrJK9nHEtIPCPSSnIU8GicqtuRIdkv_fbTs0p56Gl7mmZfhYew9iCsQ2lzPabiSQkBNnVLqFduB6E2jO929ZjshhGx6Zbpz9raUn4coe_mGnQOAaVtjduz5nuYlZTdxfHLxkQoPkaPLPjjk4xZxDSlyFz1HyjQcwGFKyfNxSr-533KIj7zQ80ZxDXW5pLLOFNPitlLjU8pzisQzLZNDqpv1kp2Nbir07jQv2MOX2_ubb83dj6_fbz7fNdhquTboAEFgB6BAD71XZmh7JZ1UWnfeazAD7s0ILY6qHTSMaLzTe4doejcIVBfs07F3yam-V1Y7h4I0TS5S2oo1Yt8DCFnB6yOIOZWSabRLDrPLfywIe7Bsq2V7sGyPluvFh1P1Nszk__EnrRX4eAJcQTeN2UUM5S_XaZByX6n-SFHV8CtQtgUDRSQfMuFqfQr_feEFhx6agQ</recordid><startdate>200101</startdate><enddate>200101</enddate><creator>Sørensen, Morten B.</creator><creator>Fritz-Hansen, Thomas</creator><creator>Jensen, Henrik H.</creator><creator>Pedersen, Anette T.</creator><creator>Højgaard, Liselotte</creator><creator>Ottesen, Bent</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200101</creationdate><title>Temporal changes in cardiac function and cerebral blood flow during sequential postmenopausal hormone replacement</title><author>Sørensen, Morten B. ; Fritz-Hansen, Thomas ; Jensen, Henrik H. ; Pedersen, Anette T. ; Højgaard, Liselotte ; Ottesen, Bent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-ca1c10c811316b9d37b4932a23668dd617bc57f14cf34b61fc7da65acc79ab0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>cardiac function</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>cerebral blood flow</topic><topic>Cerebrovascular Circulation</topic><topic>Cross-Over Studies</topic><topic>Double-Blind Method</topic><topic>Estradiol - administration & dosage</topic><topic>Estradiol - blood</topic><topic>Estrogen Replacement Therapy</topic><topic>Estrogens</topic><topic>Female</topic><topic>Genital system. Reproduction</topic><topic>Heart - physiology</topic><topic>Humans</topic><topic>Magnetic Resonance Angiography</topic><topic>Medical sciences</topic><topic>menopause</topic><topic>Middle Aged</topic><topic>norethindrone</topic><topic>Norethindrone - administration & dosage</topic><topic>Norethindrone - analogs & derivatives</topic><topic>Pharmacology. Drug treatments</topic><topic>Placebos</topic><topic>Postmenopause</topic><topic>Stroke Volume - drug effects</topic><topic>Vascular Resistance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sørensen, Morten B.</creatorcontrib><creatorcontrib>Fritz-Hansen, Thomas</creatorcontrib><creatorcontrib>Jensen, Henrik H.</creatorcontrib><creatorcontrib>Pedersen, Anette T.</creatorcontrib><creatorcontrib>Højgaard, Liselotte</creatorcontrib><creatorcontrib>Ottesen, Bent</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sørensen, Morten B.</au><au>Fritz-Hansen, Thomas</au><au>Jensen, Henrik H.</au><au>Pedersen, Anette T.</au><au>Højgaard, Liselotte</au><au>Ottesen, Bent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temporal changes in cardiac function and cerebral blood flow during sequential postmenopausal hormone replacement</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2001-01</date><risdate>2001</risdate><volume>184</volume><issue>2</issue><spage>41</spage><epage>47</epage><pages>41-47</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective: The purpose was to assess the temporal changes in cardiac function and cerebral blood flow during postmenopausal administration of estrogen with and without progestogen. Study Design: Sixteen postmenopausal volunteers were assessed during estradiol plus sequential norethindrone acetate and placebo in two 12-week periods. Temporal changes were measured by magnetic resonance flow mapping 8 times. Results: Systemic vascular resistance was reduced during estradiol (–6.9%; P <.05), declined further during the addition of norethindrone acetate, and was accompanied by an increase in stroke volume (maximum increase, 5.2%; P <.05) without fluid retention. Both systolic (–5 mm Hg; P =.03) and diastolic (–3 mm Hg; P =.03) blood pressure were reduced during estradiol. Cerebral blood flow was reduced after 9 weeks of hormone replacement therapy (–37 mL/min; P =.01) but increased to baseline after the addition of norethindrone acetate. Conclusions: Sequential hormone replacement therapy is associated with changes in cardiac function, which are of therapeutic potential in cardiovascular disorders. Sequential hormone replacement therapy exhibits an overall neutral effect on cerebral blood flow. (Am J Obstet Gynecol 2001;184:41-7.)</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>11174477</pmid><doi>10.1067/mob.2001.108333</doi><tpages>7</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 2001-01, Vol.184 (2), p.41-47 |
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| subjects | Biological and medical sciences Blood Pressure - drug effects cardiac function Cardiovascular Diseases - prevention & control cerebral blood flow Cerebrovascular Circulation Cross-Over Studies Double-Blind Method Estradiol - administration & dosage Estradiol - blood Estrogen Replacement Therapy Estrogens Female Genital system. Reproduction Heart - physiology Humans Magnetic Resonance Angiography Medical sciences menopause Middle Aged norethindrone Norethindrone - administration & dosage Norethindrone - analogs & derivatives Pharmacology. Drug treatments Placebos Postmenopause Stroke Volume - drug effects Vascular Resistance - drug effects |
| title | Temporal changes in cardiac function and cerebral blood flow during sequential postmenopausal hormone replacement |
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