Temporal changes in cardiac function and cerebral blood flow during sequential postmenopausal hormone replacement

Temporal changes in cardiac function and cerebral blood flow during sequential postmenopausal hormone replacement

Objective: The purpose was to assess the temporal changes in cardiac function and cerebral blood flow during postmenopausal administration of estrogen with and without progestogen. Study Design: Sixteen postmenopausal volunteers were assessed during estradiol plus sequential norethindrone acetate an...

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Veröffentlicht in:American journal of obstetrics and gynecology 2001-01, Vol.184 (2), p.41-47
Hauptverfasser: Sørensen, Morten B., Fritz-Hansen, Thomas, Jensen, Henrik H., Pedersen, Anette T., Højgaard, Liselotte, Ottesen, Bent
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Blood Pressure - drug effects
cardiac function
Cardiovascular Diseases - prevention & control
cerebral blood flow
Cerebrovascular Circulation
Cross-Over Studies
Double-Blind Method
Estradiol - administration & dosage
Estradiol - blood
Estrogen Replacement Therapy
Estrogens
Female
Genital system. Reproduction
Heart - physiology
Humans
Magnetic Resonance Angiography
Medical sciences
menopause
Middle Aged
norethindrone
Norethindrone - administration & dosage
Norethindrone - analogs & derivatives
Pharmacology. Drug treatments
Placebos
Postmenopause
Stroke Volume - drug effects
Vascular Resistance - drug effects
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Beschreibung
Zusammenfassung:Objective: The purpose was to assess the temporal changes in cardiac function and cerebral blood flow during postmenopausal administration of estrogen with and without progestogen. Study Design: Sixteen postmenopausal volunteers were assessed during estradiol plus sequential norethindrone acetate and placebo in two 12-week periods. Temporal changes were measured by magnetic resonance flow mapping 8 times. Results: Systemic vascular resistance was reduced during estradiol (–6.9%; P
ISSN:0002-9378
1097-6868
DOI:10.1067/mob.2001.108333