Cytotoxic labdane diterpenoids from Croton oblongifolius
Three labdane diterpenoids, 2-acetoxy-3-hydroxy-labda-8(17),12(E)-14-triene, 3-acetoxy-2-hydroxy-labda-8(17),12(E)-14-triene, and 2,3-dihydroxy-labda-8(17),12(E),14-triene were isolated from stem bark of Croton oblongifolius. Their structures were established by spectroscopic data, and each was also...
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| Veröffentlicht in: | Phytochemistry (Oxford) 2001-01, Vol.56 (1), p.103-107 |
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| container_title | Phytochemistry (Oxford) |
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| creator | ROENGSUMRAN, Sophon PETSOM, Amorn KUPTIYANUWAT, Narupat VILAIVAN, Tirayut NGAMROJNAVANICH, Nattaya CHAICHANTIPYUTH, Chaiyo PHUTHONG, Songchan |
| description | Three labdane diterpenoids, 2-acetoxy-3-hydroxy-labda-8(17),12(E)-14-triene, 3-acetoxy-2-hydroxy-labda-8(17),12(E)-14-triene, and 2,3-dihydroxy-labda-8(17),12(E),14-triene were isolated from stem bark of Croton oblongifolius. Their structures were established by spectroscopic data, and each was also tested for cytotoxicity against various human tumor cell lines. The latter compound showed non-specific, moderate, cytotoxicities against all the cell lines; whereas the first two compounds were less active. |
| doi_str_mv | 10.1016/S0031-9422(00)00358-7 |
| format | Article |
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Their structures were established by spectroscopic data, and each was also tested for cytotoxicity against various human tumor cell lines. The latter compound showed non-specific, moderate, cytotoxicities against all the cell lines; whereas the first two compounds were less active.</description><identifier>ISSN: 0031-9422</identifier><identifier>EISSN: 1873-3700</identifier><identifier>DOI: 10.1016/S0031-9422(00)00358-7</identifier><identifier>PMID: 11198816</identifier><language>eng</language><publisher>Amsterdam: Elsevier</publisher><subject>Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; Biological and medical sciences ; Chemical constitution ; Diterpenes - chemistry ; Diterpenes - isolation & purification ; Diterpenes - pharmacology ; Drug Screening Assays, Antitumor ; Fundamental and applied biological sciences. 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Their structures were established by spectroscopic data, and each was also tested for cytotoxicity against various human tumor cell lines. The latter compound showed non-specific, moderate, cytotoxicities against all the cell lines; whereas the first two compounds were less active.</description><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - isolation & purification</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chemical constitution</subject><subject>Diterpenes - chemistry</subject><subject>Diterpenes - isolation & purification</subject><subject>Diterpenes - pharmacology</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Naphthols - chemistry</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant physiology and development</subject><subject>Rosales - chemistry</subject><subject>Spectrum Analysis</subject><subject>Tumor Cells, Cultured</subject><issn>0031-9422</issn><issn>1873-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0F1LwzAUgOEgipvTn6AUBNGL6knSfOxSil8w8EK9DkmaSKVtZtKC-_d2s8yrEHjOSXgROsdwiwHzuzcAivNlQcg1wM14YTIXB2iOpaA5FQCHaL4nM3SS0hcAMMb5MZphjJdSYj5Hstz0oQ8_tc0abSrduayqexfXrgt1lTIfQ5uVcSRdFkwTus_ah6Ye0ik68rpJ7mw6F-jj8eG9fM5Xr08v5f0qt5TSPmfSFLwCbbBltGBeEoEr8MRojikQAYUXo9HCskLLwvkCBLZEeOMJN8LSBbr627uO4XtwqVdtnaxrmvGrYUhKAJOci-UI2R-0MaQUnVfrWLc6bhQGtU2mdsnUtocCULtkSoxzF9MDg2ld9T81NRrB5QR0srrxUXe2TnsnGQZG6C-4NnMJ</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>ROENGSUMRAN, Sophon</creator><creator>PETSOM, Amorn</creator><creator>KUPTIYANUWAT, Narupat</creator><creator>VILAIVAN, Tirayut</creator><creator>NGAMROJNAVANICH, Nattaya</creator><creator>CHAICHANTIPYUTH, Chaiyo</creator><creator>PHUTHONG, Songchan</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010101</creationdate><title>Cytotoxic labdane diterpenoids from Croton oblongifolius</title><author>ROENGSUMRAN, Sophon ; PETSOM, Amorn ; KUPTIYANUWAT, Narupat ; VILAIVAN, Tirayut ; NGAMROJNAVANICH, Nattaya ; CHAICHANTIPYUTH, Chaiyo ; PHUTHONG, Songchan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-58b46d0ab1c5345f8271d0f2ba61302704f758ba7c54a84ef4071c27fbf26b7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - isolation & purification</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Chemical constitution</topic><topic>Diterpenes - chemistry</topic><topic>Diterpenes - isolation & purification</topic><topic>Diterpenes - pharmacology</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Fundamental and applied biological sciences. 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| language | eng |
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| subjects | Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Chemical constitution Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Drug Screening Assays, Antitumor Fundamental and applied biological sciences. Psychology General pharmacology Humans Medical sciences Naphthols - chemistry Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant physiology and development Rosales - chemistry Spectrum Analysis Tumor Cells, Cultured |
| title | Cytotoxic labdane diterpenoids from Croton oblongifolius |
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