Cytotoxic labdane diterpenoids from Croton oblongifolius

Three labdane diterpenoids, 2-acetoxy-3-hydroxy-labda-8(17),12(E)-14-triene, 3-acetoxy-2-hydroxy-labda-8(17),12(E)-14-triene, and 2,3-dihydroxy-labda-8(17),12(E),14-triene were isolated from stem bark of Croton oblongifolius. Their structures were established by spectroscopic data, and each was also...

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Veröffentlicht in:	Phytochemistry (Oxford) 2001-01, Vol.56 (1), p.103-107
Hauptverfasser:	ROENGSUMRAN, Sophon, PETSOM, Amorn, KUPTIYANUWAT, Narupat, VILAIVAN, Tirayut, NGAMROJNAVANICH, Nattaya, CHAICHANTIPYUTH, Chaiyo, PHUTHONG, Songchan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Chemical constitution Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Drug Screening Assays, Antitumor Fundamental and applied biological sciences. Psychology General pharmacology Humans Medical sciences Naphthols - chemistry Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant physiology and development Rosales - chemistry Spectrum Analysis Tumor Cells, Cultured
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Zusammenfassung:	Three labdane diterpenoids, 2-acetoxy-3-hydroxy-labda-8(17),12(E)-14-triene, 3-acetoxy-2-hydroxy-labda-8(17),12(E)-14-triene, and 2,3-dihydroxy-labda-8(17),12(E),14-triene were isolated from stem bark of Croton oblongifolius. Their structures were established by spectroscopic data, and each was also tested for cytotoxicity against various human tumor cell lines. The latter compound showed non-specific, moderate, cytotoxicities against all the cell lines; whereas the first two compounds were less active.
ISSN:	0031-9422 1873-3700
DOI:	10.1016/S0031-9422(00)00358-7