Synthesis and transfecting properties of a glycosylated polycationic DNA vector
A glycosylated analogue of dialkylamidoglycylcarboxyspermine was synthesized. The physico-chemical and transfecting properties of 11 were evaluated indicating that this cationic lipid forms stable particles at low charge ratio and is efficient for gene delivery.
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2001-02, Vol.11 (3), p.419-422 |
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| container_end_page | 422 |
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| container_issue | 3 |
| container_start_page | 419 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 11 |
| creator | JACOPIN, Christophe HOFLAND, Hans SCHERMAN, Daniel HERSCOVICI, Jean |
| description | A glycosylated analogue of dialkylamidoglycylcarboxyspermine was synthesized. The physico-chemical and transfecting properties of 11 were evaluated indicating that this cationic lipid forms stable particles at low charge ratio and is efficient for gene delivery. |
| doi_str_mv | 10.1016/S0960-894X(00)00683-1 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2001-02, Vol.11 (3), p.419-422 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology Gene therapy Genetic Vectors - metabolism Glycine - analogs & derivatives Glycine - chemical synthesis Glycine - metabolism Glycosylation Health. Pharmaceutical industry HeLa Cells Humans Industrial applications and implications. Economical aspects Lipid Metabolism Lipids - chemical synthesis Micelles Polyamines - chemical synthesis Polyamines - metabolism Spermine - analogs & derivatives Spermine - chemical synthesis Spermine - metabolism Structure-Activity Relationship Transfection - methods |
| title | Synthesis and transfecting properties of a glycosylated polycationic DNA vector |
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