Synthesis and transfecting properties of a glycosylated polycationic DNA vector

A glycosylated analogue of dialkylamidoglycylcarboxyspermine was synthesized. The physico-chemical and transfecting properties of 11 were evaluated indicating that this cationic lipid forms stable particles at low charge ratio and is efficient for gene delivery.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2001-02, Vol.11 (3), p.419-422
Hauptverfasser:	JACOPIN, Christophe, HOFLAND, Hans, SCHERMAN, Daniel, HERSCOVICI, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology Gene therapy Genetic Vectors - metabolism Glycine - analogs & derivatives Glycine - chemical synthesis Glycine - metabolism Glycosylation Health. Pharmaceutical industry HeLa Cells Humans Industrial applications and implications. Economical aspects Lipid Metabolism Lipids - chemical synthesis Micelles Polyamines - chemical synthesis Polyamines - metabolism Spermine - analogs & derivatives Spermine - chemical synthesis Spermine - metabolism Structure-Activity Relationship Transfection - methods
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Beschreibung
Zusammenfassung:	A glycosylated analogue of dialkylamidoglycylcarboxyspermine was synthesized. The physico-chemical and transfecting properties of 11 were evaluated indicating that this cationic lipid forms stable particles at low charge ratio and is efficient for gene delivery.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(00)00683-1