Dipole analysis of ultralate (C-fibres) evoked potentials after laser stimulation of tiny cutaneous surface areas in humans

Ultralate (C-fibres) laser evoked potentials (LEP) can be obtained by stimulation of a tiny skin surface area (0.23 mm 2). Since their generators are unknown up to now, we performed brain source analyses of ultralate LEPs using high resolution electroencephalography (64 channels) and a realistic head model that was based on individual magnetic resonance images. Ultralate LEPs were characterized by a negative–positive complex with a large positive component maximal at the vertex. Source analysis revealed that ultralate LEPs could be explained by two dipole sources in the upper bank of the contralateral and ipsilateral Sylvian fissure (SII) and one dipole in the median region corresponding to the anterior cingulate gyrus.