Vascular Endothelial Growth Factor in Bacterial Meningitis: Detection in Cerebrospinal Fluid and Localization in Postmortem Brain

Vascular endothelial growth factor (VEGF) is a potent vascular permeability factor and a mediator of brain edema. To assess the role of VEGF during bacterial meningitis, VEGF was measured in cerebrospinal fluid (CSF) and blood of 37 patients with bacterial meningitis and 51 control patients, includi...

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Veröffentlicht in:	The Journal of infectious diseases 2001-01, Vol.183 (1), p.149-153
Hauptverfasser:	van der Flier, Michiel, Stockhammer, Guenther, Vonk, Gemma J. H., Nikkels, Peter G. J., van Diemen-Steenvoorde, Ronnie A. A. M., van der Vlist, Gert J., Rupert, Stijn W. M., Schmutzhard, Erich, Gunsilius, Eberhard, Gastl, Guenther, Hoepelman, Andy I. M., Kimpen, Jan L. L., Geelen, Sibyl P. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Autopsies Bacterial meningitis Bacteriological methods and techniques used in bacteriology Bacteriology Biological and medical sciences Brain - metabolism Brain edema Cerebrospinal fluid Child Child, Preschool Concise Communication Endothelial cells Endothelial Growth Factors - analysis Endothelial Growth Factors - cerebrospinal fluid Female Fundamental and applied biological sciences. Psychology Human viral diseases Humans Immunohistochemistry Infant Infectious diseases Lymphokines - analysis Lymphokines - cerebrospinal fluid Male Medical sciences Meningitis, Bacterial - blood Meningitis, Bacterial - cerebrospinal fluid Meningitis, Bacterial - metabolism Microbiology Middle Aged Neurons Neutrophils Receptor Protein-Tyrosine Kinases - analysis Receptor Protein-Tyrosine Kinases - metabolism Receptors Receptors, Growth Factor - analysis Receptors, Growth Factor - metabolism Receptors, Vascular Endothelial Growth Factor Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Viral diseases Viral diseases of the nervous system Viral meningitis
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Zusammenfassung:	Vascular endothelial growth factor (VEGF) is a potent vascular permeability factor and a mediator of brain edema. To assess the role of VEGF during bacterial meningitis, VEGF was measured in cerebrospinal fluid (CSF) and blood of 37 patients with bacterial meningitis and 51 control patients, including 16 patients with viral meningitis. Circulating VEGF levels were similar in bacterial meningitis patients and control patients. VEGFCSF was detected in 11 (30%) of 37 of bacterial meningitis patients (range,
ISSN:	0022-1899 1537-6613
DOI:	10.1086/317643