An estrogen metabolism-related polymorphism of the 17-α HSD gene is associated with perimenopausal body mass index

An estrogen metabolism-related polymorphism of the 17-α HSD gene is associated with perimenopausal body mass index

In a cross-sectional study of 2,802 perimenopausal caucasian women, carriage of at least one mutated allele of the 17-α-hydroxysteroid dehydrogenase type 1 ( 17-α HSD ) vlV A→C single nucleotide polymorphism (SNP) was associated with a significantly increased body mass index (mean 24.3 ± 4.4 kg/m2 v...

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Veröffentlicht in:Fertility and sterility 2007-06, Vol.87 (6), p.1494-1496
Hauptverfasser: Tempfer, Clemens B., M.D, Huber, Claudia, M.D, Huber, Johannes C., M.D., Ph.D, Schneeberger, Christian, Ph.D, Bentz, Eva-Katrin, M.D, Hefler, Lukas A., M.D
Format: Artikel
Sprache:eng
Schlagworte:
Body Mass Index
Cross-Sectional Studies
DNA - blood
DNA - genetics
DNA - isolation & purification
Female
Genotype
Humans
Hydroxysteroid Dehydrogenases - genetics
Internal Medicine
Middle Aged
Obstetrics and Gynecology
Parity
Perimenopause - genetics
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Pregnancy
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Zusammenfassung:In a cross-sectional study of 2,802 perimenopausal caucasian women, carriage of at least one mutated allele of the 17-α-hydroxysteroid dehydrogenase type 1 ( 17-α HSD ) vlV A→C single nucleotide polymorphism (SNP) was associated with a significantly increased body mass index (mean 24.3 ± 4.4 kg/m2 vs. 23.5 ± 4.2 kg/m2 ; P
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2006.11.055