2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3- b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

A potent series of broad-spectrum antivirals against human herpesviruses has been identified which inhibit HCMV, HSV-1, EBV, and VZV polymerases. A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3- b]pyridine-5-carboxamides have been identified as potent antivirals...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-06, Vol.17 (12), p.3349-3353
Hauptverfasser:	Schnute, Mark E., Anderson, David J., Brideau, Roger J., Ciske, Fred L., Collier, Sarah A., Cudahy, Michele M., Eggen, MariJean, Genin, Michael J., Hopkins, Todd A., Judge, Thomas M., Kim, Euibong J., Knechtel, Mary L., Nair, Sajiv K., Nieman, James A., Oien, Nancee L., Scott, Allen, Tanis, Steven P., Vaillancourt, Valerie A., Wathen, Michael W., Wieber, Janet L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Binding, Competitive Biological and medical sciences Cytomegalovirus Cytomegalovirus - drug effects DNA-Directed DNA Polymerase Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Epstein-Barr virus Ethylamines - chemical synthesis Ethylamines - pharmacology Exodeoxyribonucleases - antagonists & inhibitors HCMV Herpes simplex virus 1 Herpes Zoster - drug therapy Herpesviridae - drug effects Herpesviridae - enzymology Herpesvirus 1, Human - drug effects Herpesvirus 4, Human - drug effects HSV Human cytomegalovirus Human herpesvirus Humans Medical sciences Models, Chemical Nucleic Acid Synthesis Inhibitors Pharmacology. Drug treatments Pyridines - chemical synthesis Pyridines - pharmacology Structure-Activity Relationship Varicella-zoster Varicella-zoster virus Viral Proteins - antagonists & inhibitors VZV
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Zusammenfassung:	A potent series of broad-spectrum antivirals against human herpesviruses has been identified which inhibit HCMV, HSV-1, EBV, and VZV polymerases. A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3- b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2007.03.102