Effect of GB virus C co-infection on response to generic HAART in African patients with HIV-1 clade C infection

In 38 African AIDS patients initiating generic HAART, GB virus C (GBV-C) RNA-positive patients retained GBV-C viraemia during 52 weeks of HAART, had a faster decline in HIV viral load (P = 0.03), fewer opportunistic infections (14.3 versus 50%, P = 0.18), and suffered no serious adverse events (none...

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Veröffentlicht in:	AIDS (London) 2007-06, Vol.21 (10), p.1377-1379
Hauptverfasser:	MOSAM, Anisa, SATHAR, Mahomed A, DAWOOD, Halima, CASSOL, Edana, ESTERHUIZEN, Tonya M, COOVADIA, Hoosen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - epidemiology Adult Africa - epidemiology AIDS-Related Opportunistic Infections - epidemiology AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active - methods Antiviral agents Biological and medical sciences Female Flaviviridae Infections - complications Flaviviridae Infections - epidemiology GB virus GB virus C Hepatitis, Viral, Human - complications Hepatitis, Viral, Human - epidemiology Herpesviridae Infections - complications Herpesviridae Infections - epidemiology HIV Infections - complications HIV Infections - drug therapy HIV Infections - epidemiology HIV-1 Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Male Medical sciences Middle Aged Pharmacology. Drug treatments Prevalence Retrospective Studies RNA, Viral - analysis Sarcoma, Kaposi - complications Sarcoma, Kaposi - epidemiology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral hepatitis Viremia - complications Viremia - epidemiology
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Zusammenfassung:	In 38 African AIDS patients initiating generic HAART, GB virus C (GBV-C) RNA-positive patients retained GBV-C viraemia during 52 weeks of HAART, had a faster decline in HIV viral load (P = 0.03), fewer opportunistic infections (14.3 versus 50%, P = 0.18), and suffered no serious adverse events (none versus 61%, P = 0.008) compared with patients without GBV-C. GBV-C co-infection may be associated with a beneficial effect on African AIDS patients treated with generic HAART.
ISSN:	0269-9370 1473-5571
DOI:	10.1097/QAD.0b013e3281532cb8