Deprotonation and Regioselective Addition of 2H-Pyrazolo[3,4-c]quinolines to Electrophiles

The deprotonation and regioselective reaction of 2H-pyrazolo[3,4-c]quinolines with a variety of electrophiles is described. Electrophiles include benzaldehyde, DMF, carbon dioxide, and iodine. This method provides a direct route to a class of pharmacologically interesting compounds.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of organic chemistry 2007-06, Vol.72 (12), p.4570-4573
Hauptverfasser:	Danielson, Michael E, Hays, David S, Kshirsagar, Tushar A, Haraldson, Chad A, Lundquist, Gregory D, Wurst, Joshua R, Lindstrom, Kyle J, Mackey, Sonja S, Willie, Daniel J, Heppner, Philip D, Leir, Charles M, Benson, Karl E
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzaldehydes - chemistry Carbon Dioxide - chemistry Chemistry Dimethylformamide - chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Iodine - chemistry Organic chemistry Preparations and properties Pyrazoles - chemical synthesis Pyrazoles - chemistry Quinolines - chemical synthesis Quinolines - chemistry
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Beschreibung
Zusammenfassung:	The deprotonation and regioselective reaction of 2H-pyrazolo[3,4-c]quinolines with a variety of electrophiles is described. Electrophiles include benzaldehyde, DMF, carbon dioxide, and iodine. This method provides a direct route to a class of pharmacologically interesting compounds.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo070392t