Association of A1C With Cardiovascular Disease and Metabolic Syndrome in Asian Indians With Normal Glucose Tolerance

Association of A1C With Cardiovascular Disease and Metabolic Syndrome in Asian Indians With Normal Glucose Tolerance James Dilley , MB, CHB 1 , Anbazhagan Ganesan , BSC 1 , Raj Deepa , MPHIL, PHD 1 , Mohan Deepa , MSC 1 , Gopalakrishnan Sharada , MSC 1 , O. Dale Williams , PHD 2 and Viswanathan Mohan , MD, PHD, DSC 1 1 Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, Chennai, India 2 Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama Address correspondence and reprint requests to Dr. V. Mohan, MD, Chief of Diabetes Research, Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, 4, Conran Smith Road, Gopalapuram, Chennai 600 086, India. E-mail: drmohans{at}vsnl.net Abstract OBJECTIVE —This study examines the association of A1C with cardiovascular disease (CVD) risk factors, coronary artery disease (CAD), and metabolic syndrome in Asian Indians with normal glucose tolerance (NGT). RESEARCH DESIGN AND METHODS —This cross-sectional study recruited subjects from phase III of the Chennai Urban Rural Epidemiology Study (CURES), an epidemiological study in a representative population of Chennai (formerly Madras) in South India, conducted between January 2003 and June 2004. Included were 1,644 subjects with NGT, i.e., fasting plasma glucose