Endothelial Lipase Gene Polymorphism is Associated With Acute Myocardial Infarction, Independently of High-Density Lipoprotein-Cholesterol Levels

Endothelial Lipase Gene Polymorphism is Associated With Acute Myocardial Infarction, Independently of High-Density Lipoprotein-Cholesterol Levels

Background Endothelial lipase (EL) is a major determinant of high-density lipoprotein-cholesterol (HDL-C) metabolism and promotes monocytes recruitment. The local expression of EL could influence atherogenesis directly, in addition to its systemic role in HDL metabolism. The EL gene has a common 584...

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Veröffentlicht in:Circulation Journal 2007, Vol.71(6), pp.842-846
Hauptverfasser: Shimizu, Masakatsu, Kanazawa, Kenji, Hirata, Ken-ichi, Ishida, Tatsuro, Hiraoka, Eiji, Matsuda, Yasuaki, Iwai, Chikao, Miyamoto, Yoshitomo, Hashimoto, Masayoshi, Kajiya, Teishi, Akita, Hozuka, Yokoyama, Mitsuhiro
Format: Artikel
Sprache:eng
Schlagworte:
Acute Disease
Acute myocardial infarction
Age Factors
Case-Control Studies
Cholesterol, HDL - blood
Diabetes Mellitus - enzymology
Diabetes Mellitus - genetics
Endothelial lipase
Female
High-density lipoprotein-cholesterol
Humans
Hypercholesterolemia - enzymology
Hypercholesterolemia - genetics
Hypertension - enzymology
Hypertension - genetics
Lipase - genetics
Lipase - metabolism
Male
Middle Aged
Multivariate Analysis
Myocardial Infarction - enzymology
Myocardial Infarction - genetics
Polymorphism, Single Nucleotide
Risk Factors
Sex Factors
Single nucleotide polymorphism
Smoking
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Zusammenfassung:Background Endothelial lipase (EL) is a major determinant of high-density lipoprotein-cholesterol (HDL-C) metabolism and promotes monocytes recruitment. The local expression of EL could influence atherogenesis directly, in addition to its systemic role in HDL metabolism. The EL gene has a common 584C/T polymorphism, but it is unclear whether this polymorphism is associated with HDL-C levels or acute myocardial infarction (AMI). Methods and Results A case - control study of 107 AMI patients and 107 control subjects was conducted. T allele frequency was lower in the AMI group than in controls (0.18 vs 0.26, p
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.71.842