Effects of different types of fluid shear stress on endothelial cell proliferation and survival

We attempted to clarify the effect of different types of shear stress on endothelial cell (EC) proliferation and survival. Bovine aortic ECs were subjected to either steady laminar, 1 Hz pulsatile, or 1 Hz to and fro shear at 14 dyne/cm2. % of BrdU positive EC was 14.3 ± 1.6% in steady, 21.5 ± 3.2%...

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Veröffentlicht in:	Journal of cellular physiology 2007-07, Vol.212 (1), p.244-251
Hauptverfasser:	Kadohama, Takayuki, Nishimura, Kengo, Hoshino, Yuji, Sasajima, Tadahiro, Sumpio, Bauer E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Biomechanical Phenomena Carrier Proteins - metabolism Cattle Cell Proliferation Cell Survival - physiology Endothelial Cells - cytology Endothelial Cells - physiology Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism
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Zusammenfassung:	We attempted to clarify the effect of different types of shear stress on endothelial cell (EC) proliferation and survival. Bovine aortic ECs were subjected to either steady laminar, 1 Hz pulsatile, or 1 Hz to and fro shear at 14 dyne/cm2. % of BrdU positive EC was 14.3 ± 1.6% in steady, 21.5 ± 3.2% in pulsatile, and 11.4 ± 2.4% in to and fro after 4 h, respectively (P
ISSN:	0021-9541 1097-4652
DOI:	10.1002/jcp.21024