Interferon-beta inhibits liver metastases from murine colon 26 carcinoma and its highly metastatic variant
The antitumor effects of Interferon-beta (IFN-beta) are due to its direct inhibition of cell proliferation, immunostimulatory activity, and the inhibition of angiogenesis. We investigated the mechanism of the effects of IFN-beta on a murine colon 26 cell line (CT 26) and its highly metastatic varian...
Gespeichert in:
| Veröffentlicht in: | Surgery today (Tokyo, Japan) Japan), 2007-06, Vol.37 (6), p.474-481 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 481 |
|---|---|
| container_issue | 6 |
| container_start_page | 474 |
| container_title | Surgery today (Tokyo, Japan) |
| container_volume | 37 |
| creator | Kohashi, Shigechika Sato, Yuji Fukushima, Tsuyoshi Shomura, Hiroki Oshima, Takahiro Bairun, Sun Kondo, Masao Une, Yoshie Nishihira, Jun Todo, Satoru |
| description | The antitumor effects of Interferon-beta (IFN-beta) are due to its direct inhibition of cell proliferation, immunostimulatory activity, and the inhibition of angiogenesis. We investigated the mechanism of the effects of IFN-beta on a murine colon 26 cell line (CT 26) and its highly metastatic variant (L5).
We examined its inhibitory effects on cell proliferation in vitro and the development of liver metastases in vivo.
The proliferation of CT 26 in vitro was inhibited by IFN-beta in a dose- and time-dependent manner. The number of metastases was reduced in mice inoculated with CT 26 (P |
| doi_str_mv | 10.1007/s00595-006-3418-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_70535374</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70535374</sourcerecordid><originalsourceid>FETCH-LOGICAL-j262t-4555c674242ab8e415143514d3b0332ce7b071ddb9f1402ecd058a3334c03d573</originalsourceid><addsrcrecordid>eNo1UM1OwzAYywHExuABuKCcuAW-_DXtEU0wJk3iAucqTVOWqUlHkk4aT08Rm2TLkmX7YITuKDxSAPWUAGQlCUBBuKAl-blAc6gEJZRVdIauU9oBMFECXKEZVZIxVYg52q1DtrGzcQiksVljF7aucTnh3h1sxH7y0gSbcBcHj_0YXbDYDP0QMCuw0dG4MHiNdWjxX2_rvrb98VzMzuCDjk6HfIMuO90ne3vSBfp8fflYvpHN-2q9fN6QHStYJkJKaQolmGC6Ka2gkgo-seUNcM6MVQ0o2rZN1VEBzJoWZKk558IAb6XiC_Twv7uPw_doU669S8b2vQ52GFOtQHLJlZiC96fg2Hjb1vvovI7H-vwO_wXHDWXZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70535374</pqid></control><display><type>article</type><title>Interferon-beta inhibits liver metastases from murine colon 26 carcinoma and its highly metastatic variant</title><source>MEDLINE</source><source>SpringerLink Journals (MCLS)</source><creator>Kohashi, Shigechika ; Sato, Yuji ; Fukushima, Tsuyoshi ; Shomura, Hiroki ; Oshima, Takahiro ; Bairun, Sun ; Kondo, Masao ; Une, Yoshie ; Nishihira, Jun ; Todo, Satoru</creator><creatorcontrib>Kohashi, Shigechika ; Sato, Yuji ; Fukushima, Tsuyoshi ; Shomura, Hiroki ; Oshima, Takahiro ; Bairun, Sun ; Kondo, Masao ; Une, Yoshie ; Nishihira, Jun ; Todo, Satoru</creatorcontrib><description>The antitumor effects of Interferon-beta (IFN-beta) are due to its direct inhibition of cell proliferation, immunostimulatory activity, and the inhibition of angiogenesis. We investigated the mechanism of the effects of IFN-beta on a murine colon 26 cell line (CT 26) and its highly metastatic variant (L5).
We examined its inhibitory effects on cell proliferation in vitro and the development of liver metastases in vivo.
The proliferation of CT 26 in vitro was inhibited by IFN-beta in a dose- and time-dependent manner. The number of metastases was reduced in mice inoculated with CT 26 (P<0.01) and L5 (P<0.01) on Day 14 after treatment with IFN-beta. The median survival rate of the mice inoculated with L5 administered IFN-beta every other day, or every day was higher than in the control group (P<0.05). A dorsal air sac assay demonstrated that IFN-beta inhibited angiogenesis in mice inoculated with CT 26, but the effects disappeared with aminoguanidine, an inducible nitric oxide synthase inhibitor.
These results showed that IFN-beta directly inhibits the proliferation of CT 26. In addition, the in vivo experiments suggested that IFN-beta might effectively inhibit liver metastases.</description><identifier>ISSN: 0941-1291</identifier><identifier>DOI: 10.1007/s00595-006-3418-z</identifier><identifier>PMID: 17522764</identifier><language>eng</language><publisher>Japan</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Disease Models, Animal ; Female ; Interferon Type I - pharmacology ; Interferon Type I - therapeutic use ; Liver Neoplasms, Experimental - drug therapy ; Mice ; Mice, Inbred BALB C ; Recombinant Proteins</subject><ispartof>Surgery today (Tokyo, Japan), 2007-06, Vol.37 (6), p.474-481</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17522764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kohashi, Shigechika</creatorcontrib><creatorcontrib>Sato, Yuji</creatorcontrib><creatorcontrib>Fukushima, Tsuyoshi</creatorcontrib><creatorcontrib>Shomura, Hiroki</creatorcontrib><creatorcontrib>Oshima, Takahiro</creatorcontrib><creatorcontrib>Bairun, Sun</creatorcontrib><creatorcontrib>Kondo, Masao</creatorcontrib><creatorcontrib>Une, Yoshie</creatorcontrib><creatorcontrib>Nishihira, Jun</creatorcontrib><creatorcontrib>Todo, Satoru</creatorcontrib><title>Interferon-beta inhibits liver metastases from murine colon 26 carcinoma and its highly metastatic variant</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><description>The antitumor effects of Interferon-beta (IFN-beta) are due to its direct inhibition of cell proliferation, immunostimulatory activity, and the inhibition of angiogenesis. We investigated the mechanism of the effects of IFN-beta on a murine colon 26 cell line (CT 26) and its highly metastatic variant (L5).
We examined its inhibitory effects on cell proliferation in vitro and the development of liver metastases in vivo.
The proliferation of CT 26 in vitro was inhibited by IFN-beta in a dose- and time-dependent manner. The number of metastases was reduced in mice inoculated with CT 26 (P<0.01) and L5 (P<0.01) on Day 14 after treatment with IFN-beta. The median survival rate of the mice inoculated with L5 administered IFN-beta every other day, or every day was higher than in the control group (P<0.05). A dorsal air sac assay demonstrated that IFN-beta inhibited angiogenesis in mice inoculated with CT 26, but the effects disappeared with aminoguanidine, an inducible nitric oxide synthase inhibitor.
These results showed that IFN-beta directly inhibits the proliferation of CT 26. In addition, the in vivo experiments suggested that IFN-beta might effectively inhibit liver metastases.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Interferon Type I - pharmacology</subject><subject>Interferon Type I - therapeutic use</subject><subject>Liver Neoplasms, Experimental - drug therapy</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Recombinant Proteins</subject><issn>0941-1291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UM1OwzAYywHExuABuKCcuAW-_DXtEU0wJk3iAucqTVOWqUlHkk4aT08Rm2TLkmX7YITuKDxSAPWUAGQlCUBBuKAl-blAc6gEJZRVdIauU9oBMFECXKEZVZIxVYg52q1DtrGzcQiksVljF7aucTnh3h1sxH7y0gSbcBcHj_0YXbDYDP0QMCuw0dG4MHiNdWjxX2_rvrb98VzMzuCDjk6HfIMuO90ne3vSBfp8fflYvpHN-2q9fN6QHStYJkJKaQolmGC6Ka2gkgo-seUNcM6MVQ0o2rZN1VEBzJoWZKk558IAb6XiC_Twv7uPw_doU669S8b2vQ52GFOtQHLJlZiC96fg2Hjb1vvovI7H-vwO_wXHDWXZ</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Kohashi, Shigechika</creator><creator>Sato, Yuji</creator><creator>Fukushima, Tsuyoshi</creator><creator>Shomura, Hiroki</creator><creator>Oshima, Takahiro</creator><creator>Bairun, Sun</creator><creator>Kondo, Masao</creator><creator>Une, Yoshie</creator><creator>Nishihira, Jun</creator><creator>Todo, Satoru</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20070601</creationdate><title>Interferon-beta inhibits liver metastases from murine colon 26 carcinoma and its highly metastatic variant</title><author>Kohashi, Shigechika ; Sato, Yuji ; Fukushima, Tsuyoshi ; Shomura, Hiroki ; Oshima, Takahiro ; Bairun, Sun ; Kondo, Masao ; Une, Yoshie ; Nishihira, Jun ; Todo, Satoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j262t-4555c674242ab8e415143514d3b0332ce7b071ddb9f1402ecd058a3334c03d573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Interferon Type I - pharmacology</topic><topic>Interferon Type I - therapeutic use</topic><topic>Liver Neoplasms, Experimental - drug therapy</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Recombinant Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kohashi, Shigechika</creatorcontrib><creatorcontrib>Sato, Yuji</creatorcontrib><creatorcontrib>Fukushima, Tsuyoshi</creatorcontrib><creatorcontrib>Shomura, Hiroki</creatorcontrib><creatorcontrib>Oshima, Takahiro</creatorcontrib><creatorcontrib>Bairun, Sun</creatorcontrib><creatorcontrib>Kondo, Masao</creatorcontrib><creatorcontrib>Une, Yoshie</creatorcontrib><creatorcontrib>Nishihira, Jun</creatorcontrib><creatorcontrib>Todo, Satoru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kohashi, Shigechika</au><au>Sato, Yuji</au><au>Fukushima, Tsuyoshi</au><au>Shomura, Hiroki</au><au>Oshima, Takahiro</au><au>Bairun, Sun</au><au>Kondo, Masao</au><au>Une, Yoshie</au><au>Nishihira, Jun</au><au>Todo, Satoru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interferon-beta inhibits liver metastases from murine colon 26 carcinoma and its highly metastatic variant</atitle><jtitle>Surgery today (Tokyo, Japan)</jtitle><addtitle>Surg Today</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>37</volume><issue>6</issue><spage>474</spage><epage>481</epage><pages>474-481</pages><issn>0941-1291</issn><abstract>The antitumor effects of Interferon-beta (IFN-beta) are due to its direct inhibition of cell proliferation, immunostimulatory activity, and the inhibition of angiogenesis. We investigated the mechanism of the effects of IFN-beta on a murine colon 26 cell line (CT 26) and its highly metastatic variant (L5).
We examined its inhibitory effects on cell proliferation in vitro and the development of liver metastases in vivo.
The proliferation of CT 26 in vitro was inhibited by IFN-beta in a dose- and time-dependent manner. The number of metastases was reduced in mice inoculated with CT 26 (P<0.01) and L5 (P<0.01) on Day 14 after treatment with IFN-beta. The median survival rate of the mice inoculated with L5 administered IFN-beta every other day, or every day was higher than in the control group (P<0.05). A dorsal air sac assay demonstrated that IFN-beta inhibited angiogenesis in mice inoculated with CT 26, but the effects disappeared with aminoguanidine, an inducible nitric oxide synthase inhibitor.
These results showed that IFN-beta directly inhibits the proliferation of CT 26. In addition, the in vivo experiments suggested that IFN-beta might effectively inhibit liver metastases.</abstract><cop>Japan</cop><pmid>17522764</pmid><doi>10.1007/s00595-006-3418-z</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0941-1291 |
| ispartof | Surgery today (Tokyo, Japan), 2007-06, Vol.37 (6), p.474-481 |
| issn | 0941-1291 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70535374 |
| source | MEDLINE; SpringerLink Journals (MCLS) |
| subjects | Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Cell Line, Tumor Cell Proliferation - drug effects Disease Models, Animal Female Interferon Type I - pharmacology Interferon Type I - therapeutic use Liver Neoplasms, Experimental - drug therapy Mice Mice, Inbred BALB C Recombinant Proteins |
| title | Interferon-beta inhibits liver metastases from murine colon 26 carcinoma and its highly metastatic variant |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T23%3A06%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interferon-beta%20inhibits%20liver%20metastases%20from%20murine%20colon%2026%20carcinoma%20and%20its%20highly%20metastatic%20variant&rft.jtitle=Surgery%20today%20(Tokyo,%20Japan)&rft.au=Kohashi,%20Shigechika&rft.date=2007-06-01&rft.volume=37&rft.issue=6&rft.spage=474&rft.epage=481&rft.pages=474-481&rft.issn=0941-1291&rft_id=info:doi/10.1007/s00595-006-3418-z&rft_dat=%3Cproquest_pubme%3E70535374%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70535374&rft_id=info:pmid/17522764&rfr_iscdi=true |