Interferon-beta inhibits liver metastases from murine colon 26 carcinoma and its highly metastatic variant

The antitumor effects of Interferon-beta (IFN-beta) are due to its direct inhibition of cell proliferation, immunostimulatory activity, and the inhibition of angiogenesis. We investigated the mechanism of the effects of IFN-beta on a murine colon 26 cell line (CT 26) and its highly metastatic varian...

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Veröffentlicht in:	Surgery today (Tokyo, Japan) Japan), 2007-06, Vol.37 (6), p.474-481
Hauptverfasser:	Kohashi, Shigechika, Sato, Yuji, Fukushima, Tsuyoshi, Shomura, Hiroki, Oshima, Takahiro, Bairun, Sun, Kondo, Masao, Une, Yoshie, Nishihira, Jun, Todo, Satoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Cell Line, Tumor Cell Proliferation - drug effects Disease Models, Animal Female Interferon Type I - pharmacology Interferon Type I - therapeutic use Liver Neoplasms, Experimental - drug therapy Mice Mice, Inbred BALB C Recombinant Proteins
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Zusammenfassung:	The antitumor effects of Interferon-beta (IFN-beta) are due to its direct inhibition of cell proliferation, immunostimulatory activity, and the inhibition of angiogenesis. We investigated the mechanism of the effects of IFN-beta on a murine colon 26 cell line (CT 26) and its highly metastatic variant (L5). We examined its inhibitory effects on cell proliferation in vitro and the development of liver metastases in vivo. The proliferation of CT 26 in vitro was inhibited by IFN-beta in a dose- and time-dependent manner. The number of metastases was reduced in mice inoculated with CT 26 (P
ISSN:	0941-1291
DOI:	10.1007/s00595-006-3418-z