Designed Prostaglandins with Neurotrophic Activities

Improved stability and unprecedented biological activities—stimulation of neurite outgrowth and prevention of cell death—are exhibited by the novel Δ7‐prostaglandin A1 analogues 1 and 2. The synthesis of these neurotrophic compounds opens the way to the design of prostaglandins that can be used as p...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2000-11, Vol.1 (4), p.283-286
Hauptverfasser:	Furuta, Kyoji, Tomokiyo, Keiichiro, Satoh, Takumi, Watanabe, Yasuyoshi, Suzuki, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclopentanes - chemical synthesis Cyclopentanes - chemistry Cyclopentanes - pharmacology drug research G1 Phase - drug effects Nerve Growth Factors - metabolism Neurites - drug effects Neurites - physiology neurochemistry PC12 Cells prostaglandins Prostaglandins - chemical synthesis Prostaglandins - pharmacology Rats Structure-Activity Relationship structure-activity relationships synthesis design
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Beschreibung
Zusammenfassung:	Improved stability and unprecedented biological activities—stimulation of neurite outgrowth and prevention of cell death—are exhibited by the novel Δ7‐prostaglandin A1 analogues 1 and 2. The synthesis of these neurotrophic compounds opens the way to the design of prostaglandins that can be used as probes for in vivo brain research and to the development of chemotherapeutic agents for the treatment of neurodegenerative diseases.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/1439-7633(20001117)1:4<283::AID-CBIC283>3.0.CO;2-O