DegrAAAded into Silence

In fission yeast, RNA interference (RNAi)-dependent heterochromatin formation silences transgenes inserted at centromeres. In this issue, Bühler et al. (2007) demonstrate that the RNAi machinery directly targets transgene transcripts. Furthermore, they link transgene silencing to a protein complex r...

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Veröffentlicht in:	Cell 2007-05, Vol.129 (4), p.651-653
Hauptverfasser:	Bayne, Elizabeth H., White, Sharon A., Allshire, Robin C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Fungal Proteins - genetics Fungal Proteins - metabolism Gene Expression Regulation, Fungal - genetics Heterochromatin - genetics Macromolecular Substances - metabolism Polynucleotide Adenylyltransferase - genetics Polynucleotide Adenylyltransferase - metabolism RNA Interference - physiology Schizosaccharomyces - genetics Schizosaccharomyces - metabolism Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism Transcription, Genetic - genetics Transgenes - genetics
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Beschreibung
Zusammenfassung:	In fission yeast, RNA interference (RNAi)-dependent heterochromatin formation silences transgenes inserted at centromeres. In this issue, Bühler et al. (2007) demonstrate that the RNAi machinery directly targets transgene transcripts. Furthermore, they link transgene silencing to a protein complex resembling the TRAMP complex of budding yeast, which promotes transcript degradation via the exosome. Thus, RNAi-independent transcript degradation may also contribute to heterochromatin gene silencing.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/j.cell.2007.05.004