Charge-Monitoring Laser-Induced Acoustic Desorption Mass Spectrometry for Cell and Microparticle Mass Distribution Measurement

Mass exodus: A mass spectrometer for the rapid measurement of mass distributions of cells and microparticles is described. A discharge process is used to provide cells with thousands of charges so that direct charge measurement can be achieved. This device was used to measure microparticles with mas...

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Veröffentlicht in:	Angewandte Chemie International Edition 2007-01, Vol.46 (21), p.3865-3869
Hauptverfasser:	Peng, Wen-Ping, Lin, Huan-Chang, Lin, Hsin-Hung, Chu, Minglee, Yu, Alice L., Chang, Huan-Cheng, Chen, Chung-Hsuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustics Adsorption Cell Line, Tumor cells charge detection Humans ion trap Lasers Light Lymphocytes - radiation effects mass spectrometry Mass Spectrometry - instrumentation Mass Spectrometry - methods microparticles Monocytes - radiation effects Particle Size Polystyrenes - chemistry Polystyrenes - radiation effects Sensitivity and Specificity
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Beschreibung
Zusammenfassung:	Mass exodus: A mass spectrometer for the rapid measurement of mass distributions of cells and microparticles is described. A discharge process is used to provide cells with thousands of charges so that direct charge measurement can be achieved. This device was used to measure microparticles with masses as high as 1015 Da and to distinguish cancer cells from normal cells.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200700309