Studying the Thermodynamics of Surface Reactions on Nanoparticles by Electrostatic Titrations

For nanoparticles coated with binary SAMs (m-SAM NPs) containing charged or ionizable molecules, the relative equilibrium constants and the difference in the free energies of absorption of the m-SAM's components can be obtained in a straightforward way by titrating such NPs with oppositely charged nanoparticle “standards” until precipitation at the point of overall electroneutrality.