Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence

Zinc-finger protein 217 (ZNF217) is a Kruppel-like zinc-finger protein located at 20q13.2, within a region of recurrent maximal amplification. Here, we demonstrate that ZNF217 is a transcriptional repressor protein and report the purification and characterization of a ZNF217 complex. The purified ZN...

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Veröffentlicht in:	Oncogene 2007-05, Vol.26 (23), p.3378-3386
Hauptverfasser:	Cowger, J J M, Zhao, Q, Isovic, M, Torchia, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Apoptosis Base Sequence Binding Sites Biological and medical sciences Breast cancer Cadherins - genetics Cadherins - metabolism Cancer Cell Biology Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromatin Consensus Sequence Conserved sequence Diagnosis DNA - metabolism DNA-Binding Proteins - metabolism Down-Regulation E-cadherin Fundamental and applied biological sciences. Psychology Genetic aspects Genetics Gynecology. Andrology. Obstetrics Histone deacetylase Histone H3 Human Genetics Humans Immunoprecipitation Internal Medicine Kruppel protein Lysine Mammary gland diseases Medical sciences Medicine Medicine & Public Health Molecular and cellular biology Molecular Sequence Data Nucleotide sequence Oncology Oncology, Experimental original-article Promoter Regions, Genetic - genetics Properties Protein Binding Protein purification Proteins Repressors Sequence Alignment siRNA Trans-Activators - genetics Trans-Activators - isolation & purification Trans-Activators - metabolism Transcription factors Transcription, Genetic - genetics Tumors Zinc Zinc finger proteins
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