Recoverable PEG-Supported Copper Catalyst for Highly Stereocontrolled Nitroaldol Condensation

A new poly(ethylene glycol)-modified DAT2−Cu(OAc)2 complex smoothly catalyzes a base-free nitroaldol condensation in a highly enantioselective manner (ee up to 93%) also in reagent-grade solvent and in the presence of air. Effective recovery and recycling (up to five runs) of supported catalysts are...

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Veröffentlicht in:Organic letters 2007-05, Vol.9 (11), p.2151-2153
Hauptverfasser: Bandini, Marco, Benaglia, Maurizio, Sinisi, Riccardo, Tommasi, Simona, Umani-Ronchi, Achille
Format: Artikel
Sprache:eng
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Zusammenfassung:A new poly(ethylene glycol)-modified DAT2−Cu(OAc)2 complex smoothly catalyzes a base-free nitroaldol condensation in a highly enantioselective manner (ee up to 93%) also in reagent-grade solvent and in the presence of air. Effective recovery and recycling (up to five runs) of supported catalysts are documented.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol070636w