Chemically Immobilized Single-Stranded Oligonucleotides on Praseodymium Oxide Nanoparticles as an Unlabeled DNA Sensor Probe Using Impedance

A spark of attraction: Ellipsoidal Pr6O11 particles on indium tin oxide (ITO) modified with single‐stranded oliogonucleotides act as an unlabeled DNA probe. Upon recognition of complementary bases in solution, an impedance change (capacitance change) is detected. An equivalent impedance change is no...

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Veröffentlicht in:	Angewandte Chemie International Edition 2007-01, Vol.46 (21), p.3855-3859
Hauptverfasser:	Shrestha, Sudha, Yeung, Connie M. Y., Mills, Catherine E., Lewington, Jay, Tsang, Shik Chi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosensing Techniques - instrumentation Biosensing Techniques - methods DNA Probes - chemistry DNA structures Electric Impedance electrochemistry label‒free reagents Molecular Structure Nanoparticles - chemistry Oligonucleotides - chemistry Oxides - chemistry Particle Size Praseodymium - chemistry praseodymium oxide Sensitivity and Specificity surface chemistry
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Beschreibung
Zusammenfassung:	A spark of attraction: Ellipsoidal Pr6O11 particles on indium tin oxide (ITO) modified with single‐stranded oliogonucleotides act as an unlabeled DNA probe. Upon recognition of complementary bases in solution, an impedance change (capacitance change) is detected. An equivalent impedance change is not obtained upon the addition of an oligonucleotide with slightly mismatched bases.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200604827