Evidence mounts for a role of the kidney in lipoprotein(a) catabolism

Evidence mounts for a role of the kidney in lipoprotein(a) catabolism

Numerous studies have suggested a role of the kidney in lipoprotein(a) (Lp(a)) catabolism, but direct evidence is still lacking. Frischmann et al. demonstrate that the marked elevation of Lp(a) observed in hemodialysis patients results from a decrease in Lp(a) clearance rather than an increase in Lp...

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Veröffentlicht in:Kidney international 2007-05, Vol.71 (10), p.961-962
Hauptverfasser: Albers, J.J., Koschinsky, M.L., Marcovina, S.M.
Format: Artikel
Sprache:eng
Schlagworte:
Humans
Kidney - metabolism
Lipoprotein(a) - metabolism
Metabolism - physiology
Renal Dialysis
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Zusammenfassung:Numerous studies have suggested a role of the kidney in lipoprotein(a) (Lp(a)) catabolism, but direct evidence is still lacking. Frischmann et al. demonstrate that the marked elevation of Lp(a) observed in hemodialysis patients results from a decrease in Lp(a) clearance rather than an increase in Lp(a) production, consistent with the notion that the kidney degrades Lp(a). More studies are needed to prove the biological relevance.
ISSN:0085-2538
1523-1755
DOI:10.1038/sj.ki.5002240