Plasma Concentrations of Myeloperoxidase Predict Mortality After Myocardial Infarction

Plasma Concentrations of Myeloperoxidase Predict Mortality After Myocardial Infarction Tessa J. Mocatta, Anna P. Pilbrow, Vicky A. Cameron, Revathy Senthilmohan, Chris M. Frampton, A. Mark Richards, Christine C. Winterbourn Plasma levels of myeloperoxidase (MPO) and protein oxidation markers were investigated in relation to mortality in patients with acute myocardial infarction (MI) (n = 512). The MPO and protein carbonyls were elevated after MI. 3-Chlorotyrosine was not elevated in any patients, implying that hypochlorous acid produced by MPO was unlikely to be responsible for the increased protein carbonyls. Above-median levels of MPO were independently associated with increased 5-year mortality (risk ratio = 1.8, 95% confidence interval 1.0 to 3.0, p = 0.034). Patients with above-median MPO levels in combination with above-median levels of plasma N-terminal fragment of brain naturetic peptide or below-median left ventricular ejection fraction had significantly greater mortality compared with other patients.