Novel pyridyl-fused 3-amino chroman derivatives with dual action at serotonin transporter and 5-HT1A receptor

Structural modifications of the initial lead, 3-aminochroman (4), led to the identification of a novel series of pyridyl-fused amino chroman derivatives (5-8) and the structural isomers (9-12). The compounds described were evaluated for dual 5-HT transporter inhibitory and 5-HT(1A) receptor activiti...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2007-06, Vol.17 (11), p.3117-3121
Hauptverfasser: DAHUI ZHOU, HATZENBUHLER, Nicole T, ANDREE, Terrance H, STACK, Gary P, GROSS, Jonathan L, HARRISON, Boyd L, EVRARD, Deborah A, CHLENOV, Michael, GOLEMBIESKI, Jeannette, HORNBY, Geoffrey, SCHECHTER, Lee E, SMITH, Deborah L
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Sprache:eng
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Zusammenfassung:Structural modifications of the initial lead, 3-aminochroman (4), led to the identification of a novel series of pyridyl-fused amino chroman derivatives (5-8) and the structural isomers (9-12). The compounds described were evaluated for dual 5-HT transporter inhibitory and 5-HT(1A) receptor activities. The design strategy, synthesis, and in vitro biological characterization for these novel compounds are described.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2007.03.049