Piperazinyl CCR1 antagonists—optimization of human liver microsome stability

The synthesis, biological activity, and pharmacokinetic profile of CCR1 antagonists are described. The synthesis, biological activity, and pharmacokinetic profile of CCR1 antagonists are described.

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-06, Vol.17 (11), p.3109-3112
Hauptverfasser:	Brown, Matthew F., Bahnck, Kevin B., Blumberg, Laura C., Brissette, William H., Burrell, Sara A., Driscoll, James P., Fedeles, Flavia, Fisher, Michael B., Foti, Robert S., Gladue, Ronald P., Guzman-Martinez, Aikomari, Hayward, Matthew M., Lira, Paul D., Lillie, Brett M., Lu, Yi, Lundquist, Greg D., McElroy, Eric B., McGlynn, Molly A., Paradis, Timothy J., Poss, Christopher S., Roache, James H., Shavnya, Andrei, Shepard, Richard M., Trevena, Kristen A., Tylaska, Laurie A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents BX471 CCR1 antagonist CP-481715 Dogs Haplorhini Humans Medical sciences Microsomes, Liver - metabolism Pharmacology. Drug treatments Piperazines - chemical synthesis Piperazines - chemistry Piperazines - metabolism Rats Receptors, CCR1 Receptors, Chemokine - antagonists & inhibitors
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Beschreibung
Zusammenfassung:	The synthesis, biological activity, and pharmacokinetic profile of CCR1 antagonists are described. The synthesis, biological activity, and pharmacokinetic profile of CCR1 antagonists are described.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2007.03.037