Absence of paternal accessory sex glands dysregulates preimplantation embryo cell cycle and causes early oviductal-uterine transit in the golden hamster in vivo

Absence of paternal accessory sex glands dysregulates preimplantation embryo cell cycle and causes early oviductal-uterine transit in the golden hamster in vivo

We hypothesize that deletion of paternal accessory sex glands compromised developmental potential of preimplantation embryos because of dysregulation of blastomeric cell cycle regulators. Quantification by immunocytochemistry showed disrupted cyclicity of proliferating cell nuclear antigen, augmente...

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Veröffentlicht in:Fertility and sterility 2008-04, Vol.89 (4), p.1021-1024
Hauptverfasser: Wong, Chun Lung, M.Phil, Chan, Oi Chi, Ph.D, Lee, Ka Ho, Ph.D, O, Wai Sum, Ph.D, Chow, Pak Ham, Ph.D
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Blastocyst - chemistry
Blastocyst - immunology
Blastocyst - pathology
Cell Cycle
Cricetinae
Cyclin-Dependent Kinase Inhibitor p21 - analysis
Embryo Implantation
Embryonic Development
Female
Genitalia, Male - surgery
Immunohistochemistry
Internal Medicine
Male
Mesocricetus
Obstetrics and Gynecology
Ovum Transport
Pregnancy
Proliferating Cell Nuclear Antigen - analysis
Rad51 Recombinase - analysis
Time Factors
Tumor Suppressor Protein p53 - analysis
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Zusammenfassung:We hypothesize that deletion of paternal accessory sex glands compromised developmental potential of preimplantation embryos because of dysregulation of blastomeric cell cycle regulators. Quantification by immunocytochemistry showed disrupted cyclicity of proliferating cell nuclear antigen, augmented p53 and p21 expression, and premature transit from oviduct to uterus.
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2007.04.038