Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and glycaemia

The effects of chlorogenic acid (CA) on hepatic glucose output, blood glucose levels and on glucose tolerance were analysed. Hepatic uptake of CA and its effects on hepatic catabolism of L‐alanine and glucose‐6‐phosphatase (G‐6‐Pase) activity were also evaluated. CA (1 mM) inhibited about 40% of G‐6...

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Veröffentlicht in:	Cell biochemistry and function 2008-04, Vol.26 (3), p.320-328
Hauptverfasser:	Bassoli, Bruna Kempfer, Cassolla, Priscila, Borba-Murad, Glaucia Regina, Constantin, Jorgete, Salgueiro-Pagadigorria, Clairce Luzia, Bazotte, Roberto Barbosa, da Silva, Rui Sérgio dos Santos Ferreira, de Souza, Helenir Medri
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Area Under Curve Blood Glucose - drug effects chlorogenic acid Chlorogenic Acid - administration & dosage Chlorogenic Acid - pharmacology gluconeogenesis Glucose - biosynthesis Glucose Tolerance Test glucose-6-phosphatase Glucose-6-Phosphatase - metabolism glycaemia glycaemic index Glycerol - metabolism hepatic glucose release Hydrogen-Ion Concentration - drug effects Lactic Acid - metabolism Liver - drug effects Liver - enzymology Liver - metabolism liver perfusion Male Pyruvic Acid - metabolism Rats Rats, Wistar Urea - metabolism
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Zusammenfassung:	The effects of chlorogenic acid (CA) on hepatic glucose output, blood glucose levels and on glucose tolerance were analysed. Hepatic uptake of CA and its effects on hepatic catabolism of L‐alanine and glucose‐6‐phosphatase (G‐6‐Pase) activity were also evaluated. CA (1 mM) inhibited about 40% of G‐6‐Pase activity (p
ISSN:	0263-6484 1099-0844
DOI:	10.1002/cbf.1444