Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity

The synthesis and structure-activity relationships of a series of novel phenoxyphenyl diamine derivatives with affinity for both the histamine H(3) receptor and the serotonin transporter is described.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-06, Vol.17 (11), p.3130-3135
Hauptverfasser:	STOCKING, Emily M, MILLER, Jennifer M, BARBIER, Ann J, WILSON, Sandy J, BOGGS, Jamin D, MCALLISTER, Heather M, JIEJUN WU, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I, WOLIN, Ronald L
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Diamines - chemistry Histamine Antagonists - chemical synthesis Histamine Antagonists - chemistry Histamine Antagonists - pharmacology Humans Medical sciences Molecular Structure Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Receptors, Histamine H3 - chemistry Receptors, Histamine H3 - drug effects Serotonin Uptake Inhibitors - chemical synthesis Serotonin Uptake Inhibitors - chemistry Serotonin Uptake Inhibitors - pharmacology Serotoninergic system Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	The synthesis and structure-activity relationships of a series of novel phenoxyphenyl diamine derivatives with affinity for both the histamine H(3) receptor and the serotonin transporter is described.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2007.03.034