Antitubercular triterpenes and phytosterols from Pandanus tectorius Soland. var. laevis

Bioassay-guided chromatographic purification of the antitubercular chloroform extract of Pandanus tectorius Soland. var. laevis leaves afforded a new tirucallane-type triterpene, 24,24-dimethyl-5β-tirucall-9(11),25-dien-3-one ( 1 ), squalene and a mixture of the phytosterols stigmasterol and β-sitos...

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Veröffentlicht in:	Journal of natural medicines 2008-04, Vol.62 (2), p.232-235
Hauptverfasser:	Tan, Mario A., Takayama, Hiromitsu, Aimi, Norio, Kitajima, Mariko, Franzblau, Scott G., Nonato, Maribel G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents - chemistry Antitubercular Agents - isolation & purification Antitubercular Agents - pharmacology Biomedical and Life Sciences Biomedicine Complementary & Alternative Medicine Medicinal Chemistry Microbial Sensitivity Tests Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - growth & development Pandanaceae - chemistry Pharmacology/Toxicology Pharmacy Phytosterols - chemistry Phytosterols - isolation & purification Phytosterols - pharmacology Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Leaves - chemistry Plant Sciences Sitosterols - chemistry Sitosterols - isolation & purification Sitosterols - pharmacology Squalene - chemistry Squalene - isolation & purification Squalene - pharmacology Stigmasterol - chemistry Stigmasterol - isolation & purification Stigmasterol - pharmacology Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology
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Zusammenfassung:	Bioassay-guided chromatographic purification of the antitubercular chloroform extract of Pandanus tectorius Soland. var. laevis leaves afforded a new tirucallane-type triterpene, 24,24-dimethyl-5β-tirucall-9(11),25-dien-3-one ( 1 ), squalene and a mixture of the phytosterols stigmasterol and β-sitosterol. Microplate Alamar Blue Assay (MABA) showed that 1 inhibited the growth of Mycobacterium tuberculosis H 37 Rv with a MIC of 64 μg/mL, while squalene and the sterol mixture have MICs of 100 and 128 μg/mL, respectively.
ISSN:	1340-3443 1861-0293
DOI:	10.1007/s11418-007-0218-8