Palladium-Catalyzed Coupling of Ammonia and Hydroxide with Aryl Halides: The Direct Synthesis of Primary Anilines and Phenols

Palladium-Catalyzed Coupling of Ammonia and Hydroxide with Aryl Halides: The Direct Synthesis of Primary Anilines and Phenols

Back to basics: Ligand design has allowed two longstanding limitations of Pd‐catalyzed CN and CO coupling reactions to be overcome. The use of specific sterically demanding electron‐rich phosphine ligands makes it possible for ammonia and potassium hydroxide to act as coupling partners in palladiu...

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Veröffentlicht in:Angewandte Chemie International Edition 2007-05, Vol.46 (19), p.3402-3404
1. Verfasser: Willis, Michael C.
Format: Artikel
Sprache:eng
Schlagworte:
amination
arenes
etherification
homogeneous catalysis
palladium
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Zusammenfassung:Back to basics: Ligand design has allowed two longstanding limitations of Pd‐catalyzed CN and CO coupling reactions to be overcome. The use of specific sterically demanding electron‐rich phosphine ligands makes it possible for ammonia and potassium hydroxide to act as coupling partners in palladium‐catalyzed coupling with aryl halides.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200605071